| ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population E Benetti, R Tita, O Spiga, A Ciolfi, G Birolo, A Bruselles, G Doddato, ... European Journal of Human Genetics 28 (11), 1602-1614, 2020 | 269 | 2020 |
| An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors A Trezza, D Iovinelli, A Santucci, F Prischi, O Spiga Scientific reports 10 (1), 13866, 2020 | 100 | 2020 |
| The beneficial health effects of flavonoids on the cardiovascular system: Focus on K+ channels F Fusi, A Trezza, M Tramaglino, G Sgaragli, S Saponara, O Spiga Pharmacological Research 152, 104625, 2020 | 77 | 2020 |
| Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium F Galvagni, F Nardi, O Spiga, A Trezza, G Tarticchio, R Pellicani, ... Matrix Biology 64, 112-127, 2017 | 65 | 2017 |
| The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels F Fusi, O Spiga, A Trezza, G Sgaragli, S Saponara European journal of pharmacology 796, 158-174, 2017 | 53 | 2017 |
| Modulation of the spacer in N, N-bis (alkanol) amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR … S Dei, L Braconi, A Trezza, M Menicatti, M Contino, M Coronnello, ... European Journal of Medicinal Chemistry 172, 71-94, 2019 | 31 | 2019 |
| A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization P Bongini, A Trezza, M Bianchini, O Spiga, N Niccolai Biochemical and biophysical research communications 528 (1), 35-38, 2020 | 28 | 2020 |
| A computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases A Trezza, A Bernini, A Langella, DB Ascher, DEV Pires, A Sodi, I Passerini, ... Investigative Ophthalmology & Visual Science 58 (12), 5320-5328, 2017 | 28 | 2017 |
| Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease O Spiga, V Cicaloni, C Fiorini, A Trezza, A Visibelli, L Millucci, ... Orphanet journal of rare diseases 15, 1-10, 2020 | 26 | 2020 |
| Design, synthesis and biological evaluation of stereo-and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers E Teodori, M Contino, C Riganti, G Bartolucci, L Braconi, D Manetti, ... European Journal of Medicinal Chemistry 182, 111655, 2019 | 26 | 2019 |
| Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1. 1 channel stimulators G Carullo, A Ahmed, A Trezza, O Spiga, A Brizzi, S Saponara, F Fusi, ... Bioorganic Chemistry 105, 104404, 2020 | 20 | 2020 |
| A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria O Spiga, V Cicaloni, A Zatkova, L Millucci, G Bernardini, A Bernini, ... Computers in biology and medicine 103, 1-7, 2018 | 18 | 2018 |
| Cav1. 2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies F Fusi, A Trezza, O Spiga, G Sgaragli, S Bova Biochemical Pharmacology 140, 53-63, 2017 | 17 | 2017 |
| In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents F Fusi, M Durante, O Spiga, A Trezza, M Frosini, E Floriddia, E Teodori, ... Naunyn-Schmiedeberg's archives of pharmacology 389, 1033-1043, 2016 | 17 | 2016 |
| A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1. 2 and KCa1. 1 channels G Carullo, A Ahmed, A Trezza, O Spiga, A Brizzi, S Saponara, F Fusi, ... Biochemical Pharmacology 185, 114429, 2021 | 14 | 2021 |
| Pharmacological and In Silico Analysis of Oat Avenanthramides as EGFR Inhibitors: Effects on EGF-Induced Lung Cancer Cell Growth and Migration L Trabalzini, J Ercoli, A Trezza, I Schiavo, G Macrì, A Moglia, O Spiga, ... International Journal of Molecular Sciences 23 (15), 8534, 2022 | 13 | 2022 |
| Vasorelaxing Activity of R-(−)-3′-Hydroxy-2, 4, 5-trimethoxydalbergiquinol from Dalbergia tonkinensis: Involvement of Smooth Muscle CaV1. 2 Channels NM Cuong, NT Nhan, PN Khanh, TT Huong, NTT Tram, G Sgaragli, ... Planta Medica 86 (04), 284-293, 2020 | 12 | 2020 |
| Applications of in silico methods for design and development of drugs targeting protein-protein interactions V Cicaloni, A Trezza, F Pettini, O Spiga Current Topics in Medicinal Chemistry 19 (7), 534-554, 2019 | 12 | 2019 |
| From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6. 1 ATP-sensitive inward rectifier potassium channel A Trezza, V Cicaloni, P Porciatti, A Langella, F Fusi, S Saponara, O Spiga PeerJ 6, e4680, 2018 | 12 | 2018 |
| Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature A Trezza, O Spiga, P Mugnai, S Saponara, G Sgaragli, F Fusi European Journal of Pharmacology 918, 174778, 2022 | 11 | 2022 |
