Gavin O'Mahony
Gavin O'Mahony
Principal Scientist, AstraZeneca
Verified email at
Cited by
Cited by
Modulators of 14-3-3 protein–protein interactions
LM Stevers, E Sijbesma, M Botta, C MacKintosh, T Obsil, I Landrieu, ...
Journal of medicinal chemistry 61 (9), 3755-3778, 2017
Stabilization of protein-protein interactions in drug discovery
SA Andrei, E Sijbesma, M Hann, J Davis, G O’Mahony, MWD Perry, ...
Expert Opinion on Drug Discovery 12 (9), 925-940, 2017
Unlock the thermogenic potential of adipose tissue: pharmacological modulation and implications for treatment of diabetes and obesity
XR Peng, P Gennemark, G O'Mahony, S Bartesaghi
Frontiers in endocrinology 6, 174, 2015
Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change
SCK Sukuru, T Crepin, Y Milev, LC Marsh, JB Hill, RJ Anderson, ...
Journal of computer-aided molecular design 20 (3), 159-178, 2006
Identification and design of a novel series of MGAT2 inhibitors
JG Barlind, LK Buckett, SG Crosby, Ö Davidsson, H Emtenäs, A Ertan, ...
Bioorganic & medicinal chemistry letters 23 (9), 2721-2726, 2013
Discovery of 4-hydroxy-1, 6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors
U Bauer, F Giordanetto, M Bauer, G O’Mahony, KE Johansson, W Knecht, ...
Bioorganic & medicinal chemistry letters 22 (5), 1944-1948, 2012
Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate
G O'Mahony, M Nieuwenhuyzen, P Armstrong, PJ Stevenson
The Journal of organic chemistry 69 (11), 3968-3971, 2004
Synthesis of adenosine-based fluorosides containing a novel heterocyclic ring system
G O’Mahony, E Ehrman, M Grøtli
Tetrahedron letters 46 (39), 6745-6748, 2005
Synthesis and photophysical properties of novel cyclonucleosides—substituent effects on fluorescence emission
G O'Mahony, E Ehrman, M Grøtli
Tetrahedron 64 (30-31), 7151-7158, 2008
Synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups
G O’Mahony, AK Pitts
Organic letters 12 (9), 2024-2027, 2010
NMR-based substrate analog docking to Escherichia coli peptidyl-tRNA hydrolase
L Giorgi, P Plateau, G O'Mahony, C Aubard, M Fromant, A Thureau, ...
Journal of molecular biology 412 (4), 619-633, 2011
PPARγ and PPARα synergize to induce robust browning of white fat in vivo
T Kroon, M Harms, S Maurer, L Bonnet, I Alexandersson, A Lindblom, ...
Molecular metabolism 36, 100964, 2020
Triethylborane (Et3B)
G O’Mahony
Synlett 2004 (03), 572-573, 2004
Identification of mineralocorticoid receptor modulators with low impact on electrolyte homeostasis but maintained organ protection
KL Granberg, ZQ Yuan, B Lindmark, K Edman, J Kajanus, A Hogner, ...
Journal of medicinal chemistry 62 (3), 1385-1406, 2018
Structure‐Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity
A Nordqvist, G O'Mahony, M Fridén‐Saxin, M Fredenwall, A Hogner, ...
ChemMedChem 12 (1), 50-65, 2017
A Revised Structure for Alkaloid 235C Isolated from Skin Extracts of Mantellid (Mantella) Frogs of Madagascar
NR Andriamaharavo, M Andriantsiferana, PA Stevenson, G O'mahony, ...
Journal of natural products 68 (12), 1743-1748, 2005
Synthesis of the putative structures of homopumiliotoxins 235C and 233F
P Armstrong, S Feutren, H McAlonan, G O’Mahony, PJ Stevenson
Tetrahedron letters 45 (8), 1627-1630, 2004
In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
V Osinski, DK Bauknight, SSK Dasa, MJ Harms, T Kroon, MA Marshall, ...
Theranostics 10 (2), 585, 2020
Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9
S Geschwindner, GMK Andersson, HG Beisel, S Breuer, C Hallberg, ...
Protein Engineering, Design & Selection 28 (5), 117-125, 2015
Synthesis of 2′-([1, 2, 3] Triazol-1-yl)-2′-deoxyadenosines
G O′ Mahony, S Svensson, A Sundgren, M Gr⊘ tli
Nucleosides, Nucleotides and Nucleic Acids 27 (5), 449-459, 2008
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