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Gavin O'Mahony
Gavin O'Mahony
Senior Principal Scientist, AstraZeneca
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Modulators of 14-3-3 protein–protein interactions
LM Stevers, E Sijbesma, M Botta, C MacKintosh, T Obsil, I Landrieu, ...
Journal of medicinal chemistry 61 (9), 3755-3778, 2017
2402017
Stabilization of protein-protein interactions in drug discovery
SA Andrei, E Sijbesma, M Hann, J Davis, G O’Mahony, MWD Perry, ...
Expert opinion on drug discovery 12 (9), 925-940, 2017
1512017
Unlock the thermogenic potential of adipose tissue: pharmacological modulation and implications for treatment of diabetes and obesity
XR Peng, P Gennemark, G O’Mahony, S Bartesaghi
Frontiers in endocrinology 6, 174, 2015
662015
PPARγ and PPARα synergize to induce robust browning of white fat in vivo
T Kroon, M Harms, S Maurer, L Bonnet, I Alexandersson, A Lindblom, ...
Molecular metabolism 36, 100964, 2020
582020
Discovering New Classes of Brugia malayi Asparaginyl-tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change
SCK Sukuru, T Crepin, Y Milev, LC Marsh, JB Hill, RJ Anderson, ...
Journal of computer-aided molecular design 20, 159-178, 2006
562006
Identification and design of a novel series of MGAT2 inhibitors
JG Barlind, LK Buckett, SG Crosby, Ö Davidsson, H Emtenäs, A Ertan, ...
Bioorganic & medicinal chemistry letters 23 (9), 2721-2726, 2013
512013
Discovery of 4-hydroxy-1, 6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors
U Bauer, F Giordanetto, M Bauer, G O’Mahony, KE Johansson, W Knecht, ...
Bioorganic & medicinal chemistry letters 22 (5), 1944-1948, 2012
342012
Synthesis of tertiary amides from anionically activated aromatic trifluoromethyl groups
G O’Mahony, AK Pitts
Organic Letters 12 (9), 2024-2027, 2010
272010
Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate
G O'Mahony, M Nieuwenhuyzen, P Armstrong, PJ Stevenson
The Journal of Organic Chemistry 69 (11), 3968-3971, 2004
272004
Synthesis of adenosine-based fluorosides containing a novel heterocyclic ring system
G O’Mahony, E Ehrman, M Grøtli
Tetrahedron letters 46 (39), 6745-6748, 2005
242005
Design of Drug‐Like Protein–Protein Interaction Stabilizers Guided By Chelation‐Controlled Bioactive Conformation Stabilization
F Bosica, SA Andrei, JF Neves, P Brandt, A Gunnarsson, I Landrieu, ...
Chemistry–A European Journal 26 (31), 7131-7139, 2020
222020
NMR-based substrate analog docking to Escherichia coli peptidyl-tRNA hydrolase
L Giorgi, P Plateau, G O'Mahony, C Aubard, M Fromant, A Thureau, ...
Journal of molecular biology 412 (4), 619-633, 2011
202011
Synthesis and photophysical properties of novel cyclonucleosides—substituent effects on fluorescence emission
G O'Mahony, E Ehrman, M Grøtli
Tetrahedron 64 (30-31), 7151-7158, 2008
202008
In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
V Osinski, DK Bauknight, SSK Dasa, MJ Harms, T Kroon, MA Marshall, ...
Theranostics 10 (2), 585, 2020
192020
Identification of mineralocorticoid receptor modulators with low impact on electrolyte homeostasis but maintained organ protection
KL Granberg, ZQ Yuan, B Lindmark, K Edman, J Kajanus, A Hogner, ...
Journal of Medicinal Chemistry 62 (3), 1385-1406, 2018
192018
Phosphorylated full‐length Tau interacts with 14‐3‐3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14‐3‐3 dimer
JF Neves, O Petrvalská, F Bosica, FX Cantrelle, H Merzougui, ...
The FEBS Journal 288 (6), 1918-1934, 2021
142021
A Revised Structure for Alkaloid 235C Isolated from Skin Extracts of Mantellid (Mantella) Frogs of Madagascar
NR Andriamaharavo, M Andriantsiferana, PA Stevenson, G O'mahony, ...
Journal of natural products 68 (12), 1743-1748, 2005
142005
Triethylborane (Et3B)
G O’Mahony
Synlett 2004 (03), 572-573, 2004
142004
Structure‐Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity
A Nordqvist, G O'Mahony, M Fridén‐Saxin, M Fredenwall, A Hogner, ...
ChemMedChem 12 (1), 50-65, 2017
132017
The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells
AM Mengeste, J Lund, P Katare, R Ghobadi, HG Bakke, PK Lunde, L Eide, ...
Current research in pharmacology and drug discovery 2, 100060, 2021
112021
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