Christian Ottmann
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Modulators of protein–protein interactions
LG Milroy, TN Grossmann, S Hennig, L Brunsveld, C Ottmann
Chemical reviews 114 (9), 4695-4748, 2014
Structural view of a fungal toxin acting on a 14‐3‐3 regulatory complex
M Würtele, C Jelich‐Ottmann, A Wittinghofer, C Oecking
The EMBO journal 22 (5), 987-994, 2003
Phosphorylation of Thr-948 at the C Terminus of the Plasma Membrane H+-ATPase Creates a Binding Site for the Regulatory 14-3-3 Protein
F Svennelid, A Olsson, M Piotrowski, M Rosenquist, C Ottman, C Larsson, ...
The Plant Cell 11 (12), 2379-2391, 1999
A common toxin fold mediates microbial attack and plant defense
C Ottmann, B Luberacki, I Küfner, W Koch, F Brunner, M Weyand, ...
Proceedings of the National Academy of Sciences 106 (25), 10359-10364, 2009
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+-ATPase by combining X-ray crystallography and electron cryomicroscopy
C Ottmann, S Marco, N Jaspert, C Marcon, N Schauer, M Weyand, ...
Molecular cell 25 (3), 427-440, 2007
Small‐Molecule Stabilization of Protein–Protein Interactions: An Underestimated Concept in Drug Discovery?
P Thiel, M Kaiser, C Ottmann
Angewandte Chemie International Edition 51 (9), 2012-2018, 2012
Molecular tweezers modulate 14-3-3 protein–protein interactions
D Bier, R Rose, K Bravo-Rodriguez, M Bartel, JM Ramirez-Anguita, S Dutt, ...
Nature chemistry 5 (3), 234-239, 2013
Phosphorylation‐independent interaction between 14‐3‐3 and exoenzyme S: from structure to pathogenesis
C Ottmann, L Yasmin, M Weyand, JL Veesenmeyer, MH Diaz, RH Palmer, ...
The EMBO journal 26 (3), 902-913, 2007
Supramolecular chemistry targeting proteins
S van Dun, C Ottmann, LG Milroy, L Brunsveld
Journal of the American Chemical Society 139 (40), 13960-13968, 2017
Modulators of 14-3-3 protein–protein interactions
LM Stevers, E Sijbesma, M Botta, C MacKintosh, T Obsil, I Landrieu, ...
Journal of medicinal chemistry 61 (9), 3755-3778, 2017
Constrained peptides with target‐adapted cross‐links as inhibitors of a pathogenic protein–protein interaction
A Glas, D Bier, G Hahne, C Rademacher, C Ottmann, TN Grossmann
Angewandte Chemie International Edition 53 (9), 2489-2493, 2014
Identification and Structure of Small‐Molecule Stabilizers of 14–3–3 Protein–Protein Interactions
R Rose, S Erdmann, S Bovens, A Wolf, M Rose, S Hennig, H Waldmann, ...
Angewandte Chemie International Edition 49 (24), 4129-4132, 2010
Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling
M Molzan, B Schumacher, C Ottmann, A Baljuls, L Polzien, M Weyand, ...
Molecular and cellular biology 30 (19), 4698-4711, 2010
Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface
IJ De Vries-van Leeuwen, D da Costa Pereira, KD Flach, SR Piersma, ...
Proceedings of the National Academy of Sciences 110 (22), 8894-8899, 2013
Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR
LM Stevers, CV Lam, SFR Leysen, FA Meijer, DS van Scheppingen, ...
Proceedings of the National Academy of Sciences 113 (9), E1152-E1161, 2016
Stabilization of protein-protein interactions in drug discovery
SA Andrei, E Sijbesma, M Hann, J Davis, G O’Mahony, MWD Perry, ...
Expert Opinion on Drug Discovery 12 (9), 925-940, 2017
High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38α
JR Simard, V Pawar, B Aust, A Wolf, M Rabiller, S Wulfert, A Robubi, ...
Journal of the American Chemical Society 131 (51), 18478-18488, 2009
Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer
B Schumacher, J Mondry, P Thiel, M Weyand, C Ottmann
FEBS letters 584 (8), 1443-1448, 2010
Stabilization and inhibition of protein–protein interactions: the 14-3-3 case study
LG Milroy, L Brunsveld, C Ottmann
ACS chemical biology 8 (1), 27-35, 2013
Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers
M Molzan, S Kasper, L Röglin, M Skwarczynska, T Sassa, T Inoue, ...
ACS chemical biology 8 (9), 1869-1875, 2013
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