| A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface C Anders, Y Higuchi, K Koschinsky, M Bartel, B Schumacher, P Thiel, ... Chemistry & biology 20 (4), 583-593, 2013 | 101 | 2013 |
| Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic … T Kasukabe, Y Honma, J Okabe-Kado, Y Higuchi, N Kato, S Kumakura Oncology reports 36 (2), 968-976, 2016 | 90 | 2016 |
| Small‐Molecule Stabilization of the 14‐3‐3/Gab2 Protein–Protein Interaction (PPI) Interface D Bier, M Bartel, K Sies, S Halbach, Y Higuchi, Y Haranosono, T Brummer, ... ChemMedChem 11 (8), 911-918, 2016 | 61 | 2016 |
| Native CRISPR-Cas-mediated genome editing enables dissecting and sensitizing clinical multidrug-resistant P. aeruginosa Z Xu, M Li, Y Li, H Cao, L Miao, Z Xu, Y Higuchi, S Yamasaki, K Nishino, ... Cell reports 29 (6), 1707-1717. e3, 2019 | 58 | 2019 |
| Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola A Minami, N Tajima, Y Higuchi, T Toyomasu, T Sassa, N Kato, T Dairi Bioorganic & medicinal chemistry letters 19 (3), 870-874, 2009 | 56 | 2009 |
| Dioxygenases, key enzymes to determine the aglycon structures of fusicoccin and brassicicene, diterpene compounds produced by fungi Y Ono, A Minami, M Noike, Y Higuchi, T Toyomasu, T Sassa, N Kato, ... Journal of the American Chemical Society 133 (8), 2548-2555, 2011 | 50 | 2011 |
| Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14‐3‐3 Protein–Protein Interactions SA Andrei, P de Vink, E Sijbesma, L Han, L Brunsveld, N Kato, C Ottmann, ... Angewandte Chemie International Edition 57 (41), 13470-13474, 2018 | 46 | 2018 |
| Specific direct small molecule p300/β-catenin antagonists maintain stem cell potency Y Higuchi, C Nguyen, SY Yasuda, M McMillan, K Hasegawa, M Kahn Current molecular pharmacology 9 (3), 272-279, 2016 | 37 | 2016 |
| Molecular breeding of a fungus producing a precursor diterpene suitable for semi-synthesis by dissection of the biosynthetic machinery M Noike, Y Ono, Y Araki, R Tanio, Y Higuchi, H Nitta, Y Hamano, ... Public Library of Science 7 (8), e42090, 2012 | 34 | 2012 |
| Selectivity via cooperativity: preferential stabilization of the p65/14-3-3 interaction with semisynthetic natural products M Wolter, P De Vink, JF Neves, S Srdanovic, Y Higuchi, N Kato, A Wilson, ... Journal of the American Chemical Society 142 (27), 11772-11783, 2020 | 32 | 2020 |
| Cooperativity basis for small-molecule stabilization of protein–protein interactions PJ de Vink, SA Andrei, Y Higuchi, C Ottmann, LG Milroy, L Brunsveld Chemical Science 10 (10), 2869-2874, 2019 | 31 | 2019 |
| Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis M Hashimoto, Y Higuchi, S Takahashi, H Osada, T Sakaki, T Toyomasu, ... Bioorganic & medicinal chemistry letters 19 (19), 5640-5643, 2009 | 30 | 2009 |
| Total biosynthesis of brassicicenes: identification of a key enzyme for skeletal diversification A Tazawa, Y Ye, T Ozaki, C Liu, Y Ogasawara, T Dairi, Y Higuchi, N Kato, ... Organic letters 20 (19), 6178-6182, 2018 | 26 | 2018 |
| Polypharmacological perturbation of the 14-3-3 adaptor protein interactome stimulates neurite outgrowth A Kaplan, SA Andrei, A van Regteren Altena, T Simas, SL Banerjee, ... Cell chemical biology 27 (6), 657-667. e6, 2020 | 25 | 2020 |
| Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A T Inoue, Y Higuchi, T Yoneyama, B Lin, K Nunomura, Y Honma, N Kato Bioorganic & Medicinal Chemistry Letters 28 (4), 646-650, 2018 | 17 | 2018 |
| Structural Effects of Fusicoccin upon Upregulation of 14‐3‐3‐Phospholigand Interaction and Cytotoxic Activity J Ohkanda, A Kusumoto, L Punzalan, R Masuda, C Wang, P Parvatkar, ... Chemistry–A European Journal 24 (60), 16066-16071, 2018 | 15 | 2018 |
| Discovering protein–protein interaction stabilisers by native mass spectrometry J Bellamy-Carter, M Mohata, M Falcicchio, J Basran, Y Higuchi, ... Chemical science 12 (32), 10724-10731, 2021 | 14 | 2021 |
| p300 serine 89: a critical signaling integrator and its effects on intestinal homeostasis and repair KKY Lai, X Hu, K Chosa, C Nguyen, DP Lin, KK Lai, N Kato, Y Higuchi, ... Cancers 13 (6), 1288, 2021 | 8 | 2021 |
| Sulfonic acid salt compound of 4-carbamoyl-5-hydroxy-imidazole derivative N Kato, Y Higuchi, C Kondo, M Sunagawa US Patent 8,664,405, 2014 | 8 | 2014 |
| IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization B Andlovic, G Heilmann, S Ninck, SA Andrei, F Centorrino, Y Higuchi, ... Cell Chemical Biology 30 (6), 573-590. e6, 2023 | 6 | 2023 |
