Yusuke Higuchi
Yusuke Higuchi
Beckman Research Institute, City of Hope
Verified email at coh.org
Cited by
Cited by
A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface
C Anders, Y Higuchi, K Koschinsky, M Bartel, B Schumacher, P Thiel, ...
Chemistry & biology 20 (4), 583-593, 2013
Small‐Molecule Stabilization of the 14‐3‐3/Gab2 Protein–Protein Interaction (PPI) Interface
D Bier, M Bartel, K Sies, S Halbach, Y Higuchi, Y Haranosono, T Brummer, ...
ChemMedChem 11 (8), 911-918, 2016
Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic …
T Kasukabe, Y Honma, J Okabe-Kado, Y Higuchi, N Kato, S Kumakura
Oncology reports 36 (2), 968-976, 2016
Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola
A Minami, N Tajima, Y Higuchi, T Toyomasu, T Sassa, N Kato, T Dairi
Bioorganic & medicinal chemistry letters 19 (3), 870-874, 2009
Dioxygenases, key enzymes to determine the aglycon structures of fusicoccin and brassicicene, diterpene compounds produced by fungi
Y Ono, A Minami, M Noike, Y Higuchi, T Toyomasu, T Sassa, N Kato, ...
Journal of the American Chemical Society 133 (8), 2548-2555, 2011
Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14‐3‐3 Protein–Protein Interactions
SA Andrei, P de Vink, E Sijbesma, L Han, L Brunsveld, N Kato, C Ottmann, ...
Angewandte Chemie International Edition 57 (41), 13470-13474, 2018
Specific direct small molecule p300/β-catenin antagonists maintain stem cell potency
Y Higuchi, C Nguyen, SY Yasuda, M McMillan, K Hasegawa, M Kahn
Current molecular pharmacology 9 (3), 272-279, 2016
Molecular breeding of a fungus producing a precursor diterpene suitable for semi-synthesis by dissection of the biosynthetic machinery
M Noike, Y Ono, Y Araki, R Tanio, Y Higuchi, H Nitta, Y Hamano, ...
Public Library of Science 7 (8), e42090, 2012
Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis
M Hashimoto, Y Higuchi, S Takahashi, H Osada, T Sakaki, T Toyomasu, ...
Bioorganic & medicinal chemistry letters 19 (19), 5640-5643, 2009
Native CRISPR-Cas-mediated genome editing enables dissecting and sensitizing clinical multidrug-resistant P. aeruginosa
Z Xu, M Li, Y Li, H Cao, L Miao, Z Xu, Y Higuchi, S Yamasaki, K Nishino, ...
Cell reports 29 (6), 1707-1717. e3, 2019
Cooperativity basis for small-molecule stabilization of protein–protein interactions
PJ de Vink, SA Andrei, Y Higuchi, C Ottmann, LG Milroy, L Brunsveld
Chemical science 10 (10), 2869-2874, 2019
Selectivity via cooperativity: Preferential stabilization of the p65/14-3-3 interaction with semisynthetic natural products
M Wolter, P de Vink, JF Neves, S Srdanović, Y Higuchi, N Kato, A Wilson, ...
Journal of the American Chemical Society 142 (27), 11772-11783, 2020
Total biosynthesis of brassicicenes: Identification of a key enzyme for skeletal diversification
A Tazawa, Y Ye, T Ozaki, C Liu, Y Ogasawara, T Dairi, Y Higuchi, N Kato, ...
Organic letters 20 (19), 6178-6182, 2018
Polypharmacological perturbation of the 14-3-3 adaptor protein interactome stimulates neurite outgrowth
A Kaplan, SA Andrei, A van Regteren Altena, T Simas, SL Banerjee, ...
Cell chemical biology 27 (6), 657-667. e6, 2020
Structural Effects of Fusicoccin upon Upregulation of 14‐3‐3‐Phospholigand Interaction and Cytotoxic Activity
J Ohkanda, A Kusumoto, L Punzalan, R Masuda, C Wang, P Parvatkar, ...
Chemistry–A European Journal 24 (60), 16066-16071, 2018
Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A
T Inoue, Y Higuchi, T Yoneyama, B Lin, K Nunomura, Y Honma, N Kato
Bioorganic & medicinal chemistry letters 28 (4), 646-650, 2018
Sulfonic acid salt compound of 4-carbamoyl-5-hydroxy-imidazole derivative
N Kato, Y Higuchi, C Kondo, M Sunagawa
US Patent 8,664,405, 2014
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation
Y Zhao, K Wu, C Nguyen, G Smbatyan, E Melendez, Y Higuchi, Y Chen, ...
PloS one 12 (5), e0177245, 2017
p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair
KKY Lai, X Hu, K Chosa, C Nguyen, DP Lin, KK Lai, N Kato, Y Higuchi, ...
Cancers 13 (6), 1288, 2021
Differential Kat3 Usage Orchestrates the Integration of Cellular Metabolism with Differentiation
X Hu, M Ono, NO Chimge, K Chosa, C Nguyen, E Melendez, CH Lou, ...
Cancers 13 (23), 5884, 2021
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