| Mitotic progression following DNA damage enables pattern recognition within micronuclei SM Harding, JL Benci, J Irianto, DE Discher, AJ Minn, RA Greenberg Nature 548 (7668), 466-470, 2017 | 1327 | 2017 |
| Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival T Harada, J Swift, J Irianto, JW Shin, KR Spinler, A Athirasala, ... Journal of Cell Biology 204 (5), 669-682, 2014 | 651 | 2014 |
| Matrix elasticity regulates lamin-A, C phosphorylation and turnover with feedback to actomyosin A Buxboim, J Swift, J Irianto, KR Spinler, PCDP Dingal, A Athirasala, ... Current Biology 24 (16), 1909-1917, 2014 | 392 | 2014 |
| Mechanosensing by the nucleus: From pathways to scaling relationships S Cho, J Irianto, DE Discher Journal of Cell Biology 216 (2), 305-315, 2017 | 384 | 2017 |
| DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration J Irianto, Y Xia, CR Pfeifer, A Athirasala, J Ji, C Alvey, M Tewari, ... Current biology 27 (2), 210-223, 2017 | 283 | 2017 |
| Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest S Cho, M Vashisth, A Abbas, S Majkut, K Vogel, Y Xia, IL Ivanovska, ... Developmental cell 49 (6), 920-935. e5, 2019 | 255 | 2019 |
| Nuclear rupture at sites of high curvature compromises retention of DNA repair factors Y Xia, IL Ivanovska, K Zhu, L Smith, J Irianto, CR Pfeifer, CM Alvey, J Ji, ... Journal of Cell Biology 217 (11), 3796-3808, 2018 | 165 | 2018 |
| Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes J Irianto, J Swift, RP Martins, GD McPhail, MM Knight, DE Discher, DA Lee Biophysical journal 104 (4), 759-769, 2013 | 137 | 2013 |
| Nuclear constriction segregates mobile nuclear proteins away from chromatin J Irianto, CR Pfeifer, RR Bennett, Y Xia, IL Ivanovska, AJ Liu, ... Molecular biology of the cell 27 (25), 4011-4020, 2016 | 130 | 2016 |
| SIRPA-inhibited, marrow-derived macrophages engorge, accumulate, and differentiate in antibody-targeted regression of solid tumors CM Alvey, KR Spinler, J Irianto, CR Pfeifer, B Hayes, Y Xia, S Cho, ... Current Biology 27 (14), 2065-2077. e6, 2017 | 124 | 2017 |
| Nuclear lamins in cancer J Irianto, CR Pfeifer, IL Ivanovska, J Swift, DE Discher Cellular and molecular bioengineering 9, 258-267, 2016 | 124 | 2016 |
| Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes A Buxboim, J Irianto, J Swift, A Athirasala, JW Shin, F Rehfeldt, ... Molecular biology of the cell 28 (23), 3333-3348, 2017 | 119 | 2017 |
| Constricted migration increases DNA damage and independently represses cell cycle CR Pfeifer, Y Xia, K Zhu, D Liu, J Irianto, VMM García, LMS Millán, ... Molecular biology of the cell 29 (16), 1948-1962, 2018 | 117 | 2018 |
| Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment J Chen, J Irianto, S Inamdar, P Pravincumar, DA Lee, DL Bader, ... Biophysical journal 103 (6), 1188-1197, 2012 | 107 | 2012 |
| Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle Y Xia, CR Pfeifer, K Zhu, J Irianto, D Liu, K Pannell, EJ Chen, LJ Dooling, ... Journal of Cell Biology 218 (8), 2545-2563, 2019 | 89 | 2019 |
| Genome variation across cancers scales with tissue stiffness–An invasion-mutation mechanism and implications for immune cell infiltration CR Pfeifer, CM Alvey, J Irianto, DE Discher Current opinion in systems biology 2, 103-114, 2017 | 72 | 2017 |
| SnapShot: mechanosensing matrix J Irianto, CR Pfeifer, Y Xia, DE Discher Cell 165 (7), 1820-1820. e1, 2016 | 64 | 2016 |
| Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage J Irianto, G Ramaswamy, R Serra, MM Knight Journal of biomechanics 47 (2), 579-582, 2014 | 62 | 2014 |
| As a nucleus enters a small pore, chromatin stretches and maintains integrity, even with DNA breaks J Irianto, Y Xia, CR Pfeifer, RA Greenberg, DE Discher Biophysical journal 112 (3), 446-449, 2017 | 59 | 2017 |
| Quantification of chromatin condensation level by image processing J Irianto, DA Lee, MM Knight Medical engineering & physics 36 (3), 412-417, 2014 | 47 | 2014 |
Dennis DischerUniversity of PennsylvaniaVerified email at seas.upenn.edu
