Alexandra Gaspar
Alexandra Gaspar
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Chromone: a valid scaffold in medicinal chemistry
A Gaspar, MJ Matos, J Garrido, E Uriarte, F Borges
Chemical reviews 114 (9), 4960-4992, 2014
Hydroxycinnamic acid antioxidants: an electrochemical overview
J Teixeira, A Gaspar, EM Garrido, J Garrido, F Borges
BioMed research international 2013 (1), 251754, 2013
Chromone as a privileged scaffold in drug discovery: recent advances: miniperspective
J Reis, A Gaspar, N Milhazes, F Borges
Journal of medicinal chemistry 60 (19), 7941-7957, 2017
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors
A Gaspar, T Silva, M Yánez, D Vina, F Orallo, F Ortuso, E Uriarte, S Alcaro, ...
Journal of medicinal chemistry 54 (14), 5165-5173, 2011
Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress
J Garrido, A Gaspar, EM Garrido, R Miri, M Tavakkoli, S Pourali, L Saso, ...
Biochimie 94 (4), 961-967, 2012
Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates
JC Menezes, SP Kamat, JAS Cavaleiro, A Gaspar, J Garrido, F Borges
European journal of medicinal chemistry 46 (2), 773-777, 2011
Dietary phenolic acids and derivatives. Evaluation of the antioxidant activity of sinapic acid and its alkyl esters
A Gaspar, M Martins, P Silva, EM Garrido, J Garrido, O Firuzi, R Miri, ...
Journal of agricultural and food chemistry 58 (21), 11273-11280, 2010
New insights into the antioxidant activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives
A Gaspar, EM Garrido, M Esteves, E Quezada, N Milhazes, J Garrido, ...
European Journal of Medicinal Chemistry 44 (5), 2092-2099, 2009
Discovery of new chemical entities for old targets: insights on the lead optimization of chromone-based monoamine oxidase B (MAO-B) inhibitors
J Reis, F Cagide, D Chavarria, T Silva, C Fernandes, A Gaspar, E Uriarte, ...
Journal of Medicinal Chemistry 59 (12), 5879-5893, 2016
Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors
A Gaspar, J Reis, A Fonseca, N Milhazes, D Vińa, E Uriarte, F Borges
Bioorganic & medicinal chemistry letters 21 (2), 707-709, 2011
Biodegradable antioxidant chitosan films useful as an anti-aging skin mask
CR Afonso, RS Hirano, AL Gaspar, EGL Chagas, RA Carvalho, FV Silva, ...
International journal of biological macromolecules 132, 1262-1273, 2019
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors
AM Helguera, A Pérez-Garrido, A Gaspar, J Reis, F Cagide, D Vina, ...
European journal of medicinal chemistry 59, 75-90, 2013
Chromone-2-and-3-carboxylic acids inhibit differently monoamine oxidases A and B
S Alcaro, A Gaspar, F Ortuso, N Milhazes, F Orallo, E Uriarte, M Yáńez, ...
Bioorganic & medicinal chemistry letters 20 (9), 2709-2712, 2010
Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl–cinnamic hybrids
J Teixeira, T Silva, S Benfeito, A Gaspar, EM Garrido, J Garrido, F Borges
European journal of medicinal chemistry 62, 289-296, 2013
Antioxidant phenolic esters with potential anticancer activity: A Raman spectroscopy study
R Calheiros, NFL Machado, SM Fiuza, A Gaspar, J Garrido, N Milhazes, ...
Journal of Raman Spectroscopy: An International Journal for Original Work in …, 2008
The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease
F Mesiti, D Chavarria, A Gaspar, S Alcaro, F Borges
European journal of medicinal chemistry 181, 111572, 2019
Antioxidant versus cytotoxic properties of hydroxycinnamic acid derivatives–a new paradigm in phenolic research
M Esteves, C Siquet, A Gaspar, V Rio, JB Sousa, S Reis, MPM Marques, ...
Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal …, 2008
Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry
F Cagide, T Silva, J Reis, A Gaspar, F Borges, LR Gomes, JN Low
Chemical communications 51 (14), 2832-2835, 2015
Discovery of novel A3 adenosine receptor ligands based on chromone scaffold
A Gaspar, J Reis, S Kachler, S Paoletta, E Uriarte, KN Klotz, S Moro, ...
Biochemical Pharmacology 84 (1), 21-29, 2012
Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold
JÉ Teixeira, P Soares, S Benfeito, A Gaspar, J Garrido, MP Murphy, ...
Free radical research 46 (5), 600-611, 2012
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