Emmanuelle Comets
Emmanuelle Comets
INSERM (National Institute of Health and Medical Research, France)
Verified email at - Homepage
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Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R
E Comets, K Brendel, F Mentré
Computer methods and programs in biomedicine 90 (2), 154-166, 2008
Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide
K Brendel, E Comets, C Laffont, C Laveille, F Mentré
Pharmaceutical research 23, 2036-2049, 2006
Model evaluation of continuous data pharmacometric models: metrics and graphics
THT Nguyen, MS Mouksassi, N Holford, N Al‐Huniti, I Freedman, ...
CPT: pharmacometrics & systems pharmacology 6 (2), 87-109, 2017
Are population pharmacokinetic and/or pharmacodynamic models adequately evaluated? A survey of the literature from 2002 to 2004
K Brendel, C Dartois, E Comets, A Lemenuel-Diot, C Laveille, ...
Clinical pharmacokinetics 46, 221-234, 2007
Timing of antiviral treatment initiation is critical to reduce SARS‐CoV‐2 viral load
A Gonçalves, J Bertrand, R Ke, E Comets, X De Lamballerie, D Malvy, ...
CPT: pharmacometrics & systems pharmacology 9 (9), 509-514, 2020
Association of an IRF5 gene functional polymorphism with Sjögren's syndrome
C Miceli‐Richard, E Comets, P Loiseau, X Puechal, E Hachulla, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2007
The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjögren's syndrome
C Miceli‐Richard, N Gestermann, M Ittah, E Comets, P Loiseau, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2009
Parameter estimation in nonlinear mixed effect models using saemix, an R implementation of the SAEM algorithm
E Comets, A Lavenu, M Lavielle
Journal of Statistical Software 80, 1-41, 2017
A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed‐effects models
HT Thai, F Mentré, NHG Holford, C Veyrat‐Follet, E Comets
Pharmaceutical statistics 12 (3), 129-140, 2013
Design in nonlinear mixed effects models: optimization using the Fedorov–Wynn algorithm and power of the Wald test for binary covariates
S Retout, E Comets, A Samson, F Mentré
Statistics in Medicine 26 (28), 5162-5179, 2007
Overview of model‐building strategies in population PK/PD analyses: 2002–2004 literature survey
C Dartois, K Brendel, E Comets, CM Laffont, C Laveille, B Tranchand, ...
British journal of clinical pharmacology 64 (5), 603-612, 2007
Evaluation of different tests based on observations for external model evaluation of population analyses
K Brendel, E Comets, C Laffont, F Mentré
Journal of pharmacokinetics and pharmacodynamics 37, 49-65, 2010
New colistin population pharmacokinetic data in critically ill patients suggesting an alternative loading dose rationale
N Grégoire, O Mimoz, B Mégarbane, E Comets, D Chatelier, S Lasocki, ...
Antimicrobial agents and chemotherapy 58 (12), 7324-7330, 2014
A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis
C Miceli-Richard, E Comets, C Verstuyft, R Tamouza, P Loiseau, ...
Annals of the rheumatic diseases 67 (4), 478-484, 2008
STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling
N Gestermann, A Mekinian, E Comets, P Loiseau, X Puechal, E Hachulla, ...
Genes & Immunity 11 (5), 432-438, 2010
Cerebral uptake of mefloquine enantiomers with and without the P‐gp inhibitor elacridar (GF1210918) in mice
SB De Lagerie, E Comets, C Gautrand, C Fernandez, D Auchere, ...
British journal of pharmacology 141 (7), 1214-1222, 2004
Evaluation of bootstrap methods for estimating uncertainty of parameters in nonlinear mixed-effects models: a simulation study in population pharmacokinetics
HT Thai, F Mentré, NHG Holford, C Veyrat-Follet, E Comets
Journal of pharmacokinetics and pharmacodynamics 41, 15-33, 2014
Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients
M Chou, J Bertrand, O Segeral, C Verstuyft, L Borand, E Comets, ...
Antimicrobial agents and chemotherapy 54 (10), 4432-4439, 2010
Model evaluation in nonlinear mixed effect models, with applications to pharmacokinetics
E Comets, K Brendel, F Mentré
Journal de la Société Française de Statistique 151 (1), 106-127, 2010
Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters
J Bertrand, E Comets, F Mentre
Journal of biopharmaceutical statistics 18 (6), 1084-1102, 2008
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