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Esther C.Y. Woon
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The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ...
EMBO reports 12 (5), 463-469, 2011
11282011
A safe lithium mimetic for bipolar disorder
N Singh, AC Halliday, JM Thomas, OV Kuznetsova, R Baldwin, ...
Nature communications 4 (1), 1332, 2013
3032013
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches
NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ...
Journal of medicinal chemistry 53 (4), 1810-1818, 2010
1802010
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
1602012
N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
S Zou, JDW Toh, KHQ Wong, YG Gao, W Hong, ECY Woon
Scientific reports 6 (1), 25677, 2016
1512016
Inhibition of histone demethylases by 4-carboxy-2, 2′-bipyridyl compounds
KH Chang, ONF King, A Tumber, ECY Woon, TD Heightman, ...
ChemMedChem 6 (5), 759, 2011
1082011
A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6-methyladenosine demethylase FTO
JDW Toh, L Sun, LZM Lau, J Tan, JJA Low, CWQ Tang, EJY Cheong, ...
Chemical science 6 (1), 112-122, 2015
1052015
Doxorubicin-loaded cell-derived nanovesicles: An alternative targeted approach for anti-tumor therapy
WJ Goh, CK Lee, S Zou, ECY Woon, B Czarny, G Pastorin
International journal of nanomedicine, 2759-2767, 2017
982017
Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors
M Demetriades, IKH Leung, R Chowdhury, MC Chan, MA McDonough, ...
Angewandte Chemie International Edition 51 (27), 6672-6675, 2012
962012
Linking of 2‐oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases
ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ...
Angewandte Chemie 124 (7), 1663-1666, 2012
842012
Poly (ADP-ribose) polymerase inhibition-where now?
ECY Woon, MD Threadgill
Current medicinal chemistry 12 (20), 2373-2392, 2005
812005
5-Nitroisocoumarins from tandem Castro–Stephens coupling—6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3 …
ECY Woon, A Dhami, MF Mahon, MD Threadgill
Tetrahedron 62 (20), 4829-4837, 2006
702006
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase
ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ...
Journal of medicinal chemistry 55 (5), 2173-2184, 2012
602012
5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl) isoquinolin-1-ones as isoform-selective inhibitors of poly (ADP-ribose) polymerase 2 (PARP-2)
PT Sunderland, ECY Woon, A Dhami, AB Bergin, MF Mahon, PJ Wood, ...
Journal of medicinal chemistry 54 (7), 2049-2059, 2011
602011
Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates
SR Inglis, ECY Woon, AL Thompson, CJ Schofield
The Journal of Organic Chemistry 75 (2), 468-471, 2010
562010
Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA)
C Contreras-Martel, A Amoroso, ECY Woon, A Zervosen, S Inglis, ...
ACS chemical biology 6 (9), 943-951, 2011
512011
Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors
SR Inglis, A Zervosen, ECY Woon, T Gerards, N Teller, DS Fischer, ...
Journal of medicinal chemistry 52 (19), 6097-6106, 2009
492009
Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity
A Lim, J Zhou, RA Sinha, BK Singh, S Ghosh, KH Lim, PKH Chow, ...
Biochemical and biophysical research communications 479 (3), 476-481, 2016
432016
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
HA Paine, A Nathubhai, ECY Woon, PT Sunderland, PJ Wood, MF Mahon, ...
Bioorganic & Medicinal Chemistry 23 (17), 5891-5908, 2015
332015
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
KK Yeoh, MC Chan, A Thalhammer, M Demetriades, R Chowdhury, ...
Organic & biomolecular chemistry 11 (5), 732-745, 2013
332013
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