Karl Dane Wittrup
Karl Dane Wittrup
Professor of Chemical Engineering & Biological Engineering, Massachusetts Institute of Technology
Verified email at - Homepage
Cited by
Cited by
Yeast surface display for screening combinatorial polypeptide libraries
ET Boder, KD Wittrup
Nature biotechnology 15 (6), 553-557, 1997
Isolating and engineering human antibodies using yeast surface display
G Chao, WL Lau, BJ Hackel, SL Sazinsky, SM Lippow, KD Wittrup
Nature protocols 1 (2), 755-768, 2006
Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity
ET Boder, KS Midelfort, KD Wittrup
Proceedings of the National Academy of Sciences 97 (20), 10701-10705, 2000
Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance
GM Thurber, MM Schmidt, KD Wittrup
Advanced drug delivery reviews 60 (12), 1421-1434, 2008
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
MJ Feldhaus, RW Siegel, LK Opresko, JR Coleman, JMW Feldhaus, ...
Nature biotechnology 21 (2), 163-170, 2003
A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
MM Schmidt, KD Wittrup
Molecular cancer therapeutics 8 (10), 2861-2871, 2009
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
KD Moynihan, CF Opel, GL Szeto, A Tzeng, EF Zhu, JM Engreitz, ...
Nature medicine 22 (12), 1402-1410, 2016
Monovalent, reduced-size quantum dots for imaging receptors on living cells
M Howarth, W Liu, S Puthenveetil, Y Zheng, LF Marshall, MM Schmidt, ...
Nature methods 5 (5), 397-399, 2008
Yeast surface display for protein engineering and characterization
SA Gai, KD Wittrup
Current opinion in structural biology 17 (4), 467-473, 2007
[25] Yeast surface display for directed evolution of protein expression, affinity, and stability
ET Boder, KD Wittrup
Methods in enzymology 328, 430-444, 2000
Biophysical properties of the clinical-stage antibody landscape
T Jain, T Sun, S Durand, A Hall, NR Houston, JH Nett, B Sharkey, ...
Proceedings of the National Academy of Sciences 114 (5), 944-949, 2017
Yeast cell surface display of proteins and uses thereof
KD Wittrup, DM Kranz, M Kieke, ET Boder
US Patent 6,699,658, 2004
Computational design of antibody-affinity improvement beyond in vivo maturation
SM Lippow, KD Wittrup, B Tidor
Nature biotechnology 25 (10), 1171-1176, 2007
In vitro evolution of a T cell receptor with high affinity for peptide/MHC
PD Holler, PO Holman, EV Shusta, S O'Herrin, KD Wittrup, DM Kranz
Proceedings of the National Academy of Sciences 97 (10), 5387-5392, 2000
Protein engineering by cell-surface display
KD Wittrup
Current opinion in biotechnology 12 (4), 395-399, 2001
Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments
EV Shusta, RT Raines, A Plückthun, KD Wittrup
Nature biotechnology 16 (8), 773-777, 1998
Directed evolution of a stable scaffold for T-cell receptor engineering
EV Shusta, PD Holler, MC Kieke, DM Kranz, KD Wittrup
Nature biotechnology 18 (7), 754-759, 2000
Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor
L Ma, T Dichwalkar, JYH Chang, B Cossette, D Garafola, AQ Zhang, ...
Science 365 (6449), 162-168, 2019
Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency
EV Shusta, MC Kieke, E Parke, DM Kranz, KD Wittrup
Journal of molecular biology 292 (5), 949-956, 1999
Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors
TT Smith, HF Moffett, SB Stephan, CF Opel, AG Dumigan, X Jiang, ...
The Journal of clinical investigation 127 (6), 2176-2191, 2017
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