Nabil Seidah
Nabil Seidah
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
M Abifadel, M Varret, JP Rabès, D Allard, K Ouguerram, M Devillers, ...
Nature genetics 34 (2), 154-156, 2003
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
MJ Vincent, E Bergeron, S Benjannet, BR Erickson, PE Rollin, TG Ksiazek, ...
Virology journal 2, 1-10, 2005
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
B Coutard, C Valle, X De Lamballerie, B Canard, NG Seidah, E Decroly
Antiviral research 176, 104742, 2020
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation
NG Seidah, S Benjannet, L Wickham, J Marcinkiewicz, SB Jasmin, ...
Proceedings of the National Academy of Sciences 100 (3), 928-933, 2003
The Notch1 receptor is cleaved constitutively by a furin-like convertase
F Logeat, C Bessia, C Brou, O LeBail, S Jarriault, NG Seidah, A Israël
Proceedings of the National Academy of Sciences 95 (14), 8108-8112, 1998
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides
NG Seidah, M Chrétien
Brain research 848 (1-2), 45-62, 1999
The biology and therapeutic targeting of the proprotein convertases
NG Seidah, A Prat
Nature reviews Drug discovery 11 (5), 367-383, 2012
Automated design of ligands to polypharmacological profiles
J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ...
Nature 492 (7428), 215-220, 2012
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
S Benjannet, D Rhainds, R Essalmani, J Mayne, L Wickham, W Jin, ...
Journal of Biological Chemistry 279 (47), 48865-48875, 2004
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
S Benjannet, N Rondeau, R Day, M Chretien, NG Seidah
Proceedings of the National Academy of Sciences 88 (9), 3564-3568, 1991
Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia
G Dubuc, A Chamberland, H Wassef, J Davignon, NG Seidah, L Bernier, ...
Arteriosclerosis, thrombosis, and vascular biology 24 (8), 1454-1459, 2004
Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor
SJ Mowla, HF Farhadi, S Pareek, JK Atwal, SJ Morris, NG Seidah, ...
Journal of Biological Chemistry 276 (16), 12660-12666, 2001
PCSK9: a key modulator of cardiovascular health
NG Seidah, Z Awan, M Chrétien, M Mbikay
Circulation research 114 (6), 1022-1036, 2014
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
NG Seidah, L Gaspar, P Mion, M Marcinkiewicz, M Mbikay, M Chretien
DNA and cell biology 9 (6), 415-424, 1990
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution …
NG Seidah, M Marcinkiewicz, S Benjannet, L Gaspar, G Beaubien, ...
Molecular Endocrinology 5 (1), 111-122, 1991
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
S Poirier, G Mayer, S Benjannet, E Bergeron, J Marcinkiewicz, ...
Journal of Biological Chemistry 283 (4), 2363-2372, 2008
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions
NG Seidah, M Chretien, R Day
Biochimie 76 (3-4), 197-209, 1994
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases
NG Seidah, S Benjannet, S Pareek, M Chrétien, RA Murphy
FEBS letters 379 (3), 247-250, 1996
Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2
M Costa-Mattioli, D Gobert, H Harding, B Herdy, M Azzi, M Bruno, ...
Nature 436 (7054), 1166-1170, 2005
Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte‐specific low‐density lipoprotein receptor degradation and critical role in mouse liver regeneration
A Zaid, A Roubtsova, R Essalmani, J Marcinkiewicz, A Chamberland, ...
Hepatology 48 (2), 646-654, 2008
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