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Kar Kheng Yeoh
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The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ...
EMBO reports 12 (5), 463-469, 2011
11252011
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors
YM Tian, KK Yeoh, MK Lee, T Eriksson, BM Kessler, HB Kramer, ...
Journal of biological chemistry 286 (15), 13041-13051, 2011
2192011
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
1772013
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
1602012
Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents
E Flashman, SL Davies, KK Yeoh, CJ Schofield
Biochemical journal 427 (1), 135-142, 2010
1582010
Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
WS Aik, M Demetriades, MKK Hamdan, EAL Bagg, KK Yeoh, C Lejeune, ...
Journal of medicinal chemistry 56 (9), 3680-3688, 2013
1542013
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases
R Chowdhury, JI Candela-Lena, MC Chan, DJ Greenald, KK Yeoh, ...
ACS chemical biology 8 (7), 1488-1496, 2013
1382013
Metabolic adaptation to chronic hypoxia in cardiac mitochondria
LC Heather, MA Cole, JJ Tan, LJA Ambrose, S Pope, AH Abd-Jamil, ...
Basic research in cardiology 107, 1-12, 2012
1212012
Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors
SC Tan, CA Carr, KK Yeoh, CJ Schofield, KE Davies, K Clarke
Molecular biology reports 39, 4857-4867, 2012
1022012
Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors
M Demetriades, IKH Leung, R Chowdhury, MC Chan, MA McDonough, ...
Angewandte Chemie International Edition 51 (27), 6672-6675, 2012
962012
On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
MA Cole, AH Abd Jamil, LC Heather, AJ Murray, ER Sutton, M Slingo, ...
The faseb journal 30 (8), 2684, 2016
712016
Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors
KK Yeoh, TD Butters, BL Wilkinson, AJ Fairbanks
Carbohydrate research 344 (5), 586-591, 2009
552009
Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure
CJ Stubbs, C Loenarz, J Mecinović, KK Yeoh, N Hindley, BM Liénard, ...
Journal of medicinal chemistry 52 (9), 2799-2805, 2009
532009
HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
RL Chen, OO Ogunshola, KK Yeoh, A Jani, M Papadakis, S Nagel, ...
Journal of neurochemistry 131 (2), 177-189, 2014
502014
Preconditioning of cardiosphere-derived cells with hypoxia or prolyl-4-hydroxylase inhibitors increases stemness and decreases reliance on oxidative metabolism
SC Tan, RSM Gomes, KK Yeoh, F Perbellini, S Malandraki-Miller, ...
Cell transplantation 25 (1), 35-53, 2016
372016
Using NMR solvent water relaxation to investigate metalloenzyme− ligand binding interactions
IKH Leung, E Flashman, KK Yeoh, CJ Schofield, TDW Claridge
Journal of medicinal chemistry 53 (2), 867-875, 2010
362010
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
KK Yeoh, MC Chan, A Thalhammer, M Demetriades, R Chowdhury, ...
Organic & biomolecular chemistry 11 (5), 732-745, 2013
332013
Pharmacotherapeutic potential of natural products to target the SARS-CoV-2 PLpro using molecular screening and simulation approaches
AM Sayaf, H Ahmad, MA Aslam, SA Ghani, S Bano, Q Yousafi, ...
Applied biochemistry and biotechnology 195 (11), 6959-6978, 2023
92023
Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase …
AM Sayaf, S Ullah Khalid, JA Hameed, A Alshammari, A Khan, ...
Frontiers in Pharmacology 14, 1202128, 2023
22023
37 Use of prolyl hydroxylase inhibitors to induce HIF-related metabolic changes and increase c-Kit expression in cardiosphere-derived cells
SC Tan, KK Yeoh, CA Carr, LC Heather, L Ambrose, JJ Tan, C Schofield, ...
Heart 97 (20), e7-e7, 2011
22011
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