CRISPR–Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters MM Zhang, FT Wong, Y Wang, S Luo, YH Lim, E Heng, WL Yeo, RE Cobb, ... Nature chemical biology 13 (6), 607-609, 2017 | 288 | 2017 |
Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science PA Guerette, S Hoon, Y Seow, M Raida, A Masic, FT Wong, VHB Ho, ... Nature biotechnology 31 (10), 908-915, 2013 | 197 | 2013 |
Combinatorial biosynthesis of polyketides—a perspective FT Wong, C Khosla Current opinion in chemical biology 16 (1-2), 117-123, 2012 | 168 | 2012 |
N-heterocyclic carbene (NHC)-catalyzed direct amidation of aldehydes with nitroso compounds FT Wong, PK Patra, J Seayad, Y Zhang, JY Ying Organic Letters 10 (12), 2333-2336, 2008 | 110 | 2008 |
Structure and Mechanism of the trans-Acting Acyltransferase from the Disorazole Synthase FT Wong, X Jin, II Mathews, DE Cane, C Khosla Biochemistry 50 (30), 6539-6548, 2011 | 99 | 2011 |
Protein− protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases FT Wong, AY Chen, DE Cane, C Khosla Biochemistry 49 (1), 95-102, 2010 | 78 | 2010 |
Kinetic controlled tag-catcher interactions for directed covalent protein assembly LL Tan, SS Hoon, FT Wong PloS one 11 (10), e0165074, 2016 | 68 | 2016 |
Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR‐Cas9 Activation YH Lim, FT Wong, WL Yeo, KC Ching, YW Lim, E Heng, S Chen, DJ Tsai, ... ChemBioChem 19 (16), 1716-1719, 2018 | 50 | 2018 |
Characterization of Cas proteins for CRISPR‐Cas editing in streptomycetes WL Yeo, E Heng, LL Tan, YW Lim, YH Lim, S Hoon, H Zhao, MM Zhang, ... Biotechnology and bioengineering 116 (9), 2330-2338, 2019 | 32 | 2019 |
The biosynthetic landscape of triceptides reveals radical SAM enzymes that catalyze cyclophane formation on Tyr-and His-containing motifs R Sugiyama, AFL Suarez, Y Morishita, TQN Nguyen, YW Tooh, ... Journal of the American Chemical Society 144 (26), 11580-11593, 2022 | 27 | 2022 |
Epoxide hydrolase–lasalocid A structure provides mechanistic insight into polyether natural product biosynthesis FT Wong, K Hotta, X Chen, M Fang, K Watanabe, CY Kim Journal of the American Chemical Society 137 (1), 86-89, 2015 | 23 | 2015 |
A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis PY Lim, LL Tan, DSW Ow, FT Wong Microbial cell factories 16, 1-8, 2017 | 12 | 2017 |
CRISPR-Cas strategies for natural product discovery and engineering in actinomycetes E Heng, LL Tan, MM Zhang, FT Wong Process Biochemistry 102, 261-268, 2021 | 11 | 2021 |
Biosynthetic engineering of the antifungal, anti-MRSA auroramycin WL Yeo, E Heng, LL Tan, YW Lim, KC Ching, DJ Tsai, YW Jhang, ... Microbial cell factories 19, 1-11, 2020 | 10 | 2020 |
Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin JH Wong, M Alfatah, KW Kong, S Hoon, WL Yeo, KC Ching, ... PloS one 14 (6), e0218189, 2019 | 9 | 2019 |
Identification and engineering of 32 membered antifungal macrolactone notonesomycins F Goh, MM Zhang, TR Lim, KN Low, CE Nge, E Heng, WL Yeo, FL Sirota, ... Microbial Cell Factories 19, 1-13, 2020 | 7 | 2020 |
Enhancing armeniaspirols production through multi-level engineering of a native Streptomyces producer E Heng, YW Lim, CY Leong, VWP Ng, SB Ng, YH Lim, FT Wong Microbial cell factories 22 (1), 84, 2023 | 5 | 2023 |
CRISPR/Cas-Mediated Genome Editing of Streptomyces LL Tan, E Heng, N Zulkarnain, WC Hsiao, FT Wong, MM Zhang Recombineering: Methods and Protocols, 207-225, 2022 | 5 | 2022 |
Training old dogs to do new tricks: A general multi-pronged activation approach for natural product discovery in Actinomycetes D Tay, LL Tan, E Heng, N Zulkarnain, KC Ching, M Wibowo, E Chin, ... | 3 | 2022 |
Cytoplasmic expression of a thermostable invertase from Thermotoga maritima in Lactococcus lactis HB Pek, PY Lim, C Liu, DY Lee, X Bi, FT Wong, DSW Ow Biotechnology letters 39, 759-765, 2017 | 3 | 2017 |