Ahmet Acar
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Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Y Kojima, A Acar, EN Eaton, KT Mellody, C Scheel, I Ben-Porath, ...
Proceedings of the National Academy of Sciences 107 (46), 20009-20014, 2010
Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity
BM Simoes, CS O’Brien, R Eyre, A Silva, L Yu, A Sarmiento-Castro, ...
Cell reports 12 (12), 1968-1977, 2015
TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer
S Busch, A Acar, Y Magnusson, P Gregersson, L Rydén, G Landberg
Oncogene 34 (1), 27-38, 2013
Subclonal reconstruction of tumors by using machine learning and population genetics
G Caravagna, T Heide, MJ Williams, L Zapata, D Nichol, K Chkhaidze, ...
Nature genetics 52 (9), 898-907, 2020
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
A Acar, D Nichol, J Fernandez-Mateos, GD Cresswell, I Barozzi, SP Hong, ...
Nature communications 11 (1), 1923, 2020
Dishevelled limits Notch signalling through inhibition of CSL
GM Collu, A Hidalgo-Sastre, A Acar, L Bayston, C Gildea, MK Leverentz, ...
Development 139 (23), 4405-4415, 2012
A role for notch signalling in breast cancer and endocrine resistance
A Acar, BM Simões, RB Clarke, K Brennan
Stem cells international 2016 (1), 2498764, 2016
Evolutionary dynamics of residual disease in human glioblastoma
I Spiteri, G Caravagna, GD Cresswell, A Vatsiou, D Nichol, A Acar, ...
Annals of Oncology 30 (3), 456-463, 2019
The spatiotemporal evolution of lymph node spread in early breast cancer
P Barry, A Vatsiou, I Spiteri, D Nichol, GD Cresswell, A Acar, N Trahearn, ...
Clinical Cancer Research 24 (19), 4763-4770, 2018
Inhibition of Wnt signalling by Notch via two distinct mechanisms
A Acar, A Hidalgo-Sastrem, MK Leverentz, CG Mills, W Simon, B Martin, ...
Scientific Reports, 9096, 2021
Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts
UM Polanska, A Acar, A Orimo
JoVE (Journal of Visualized Experiments), e3201, 2011
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
L Zapata, G Caravagna, MJ Williams, E Lakatos, K AbdulJabbar, ...
Nature Genetics 55 (3), 451-460, 2023
Systems biology and experimental model systems of cancer
GD Yalcin, N Danisik, RC Baygin, A Acar
Journal of Personalized Medicine 10 (4), 180, 2020
Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers
MA Temena, A Acar
Scientific Reports 12 (1), 11763, 2022
Identification of collateral sensitivity and evolutionary landscape of chemotherapy-induced drug resistance using cellular barcoding technology
N Danisik, KC Yilmaz, A Acar
Frontiers in Pharmacology 14, 1178489, 2023
Investigation of evolutionary dynamics for drug resistance in 3D spheroid model system using cellular barcoding technology
GD Yalcin, KC Yilmaz, T Dilber, A Acar
Plos one 18 (9), e0291942, 2023
Pan-Cancer Analysis of the COVID-19 Causal Gene SLC6A20
A Acar
ACS omega 8 (14), 13153-13161, 2023
Characterization of dabrafenib-induced drug insensitivity via cellular barcoding and collateral sensitivity to second-line therapeutics
RC Baygin, KC Yilmaz, A Acar
Scientific Reports 14 (1), 286, 2024
Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping
J Fernandez-Mateos, S Milite, E Oliveira, G Vlachogiannis, B Chen, ...
bioRxiv, 2023.11. 15.567140, 2023
Cancer evolution
L Ermini, D Mallo, D Kleftogiannis, A Acar
Frontiers in Genetics 14, 633, 2023
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Articles 1–20