Karen J Gregory
Karen J Gregory
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The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors
SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ...
British journal of pharmacology 176, S21-S141, 2019
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
H Wu, C Wang, KJ Gregory, GW Han, HP Cho, Y Xia, CM Niswender, ...
Science 344 (6179), 58-64, 2014
The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors
SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ...
British journal of pharmacology 178, S27-S156, 2021
The concise guide to pharmacology 2017/18: overview
SPH Alexander, E Kelly, NV Marrion, JA Peters, E Faccenda, SD Harding, ...
British journal of pharmacology 174, S1-S16, 2017
A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND∗
C Valant, KJ Gregory, NE Hall, PJ Scammells, MJ Lew, PM Sexton, ...
Journal of biological chemistry 283 (43), 29312-29321, 2008
Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands
VA Avlani, KJ Gregory, CJ Morton, MW Parker, PM Sexton, ...
Journal of Biological Chemistry 282 (35), 25677-25686, 2007
Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors
CW Lindsley, KA Emmitte, CR Hopkins, TM Bridges, KJ Gregory, ...
Chemical reviews 116 (11), 6707-6741, 2016
Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias
KJ Gregory, NE Hall, AB Tobin, PM Sexton, A Christopoulos
Journal of Biological Chemistry 285 (10), 7459-7474, 2010
Allosteric modulation of muscarinic acetylcholine receptors
KJ Gregory, PM Sexton, A Christopoulos
Current neuropharmacology 5 (3), 157-167, 2007
Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential
KJ Gregory, EN Dong, J Meiler, PJ Conn
Neuropharmacology 60 (1), 66-81, 2011
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS
S Yin, MJ Noetzel, KA Johnson, R Zamorano, N Jalan-Sakrikar, ...
Journal of Neuroscience 34 (1), 79-94, 2014
Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents
JM Rook, Z Xiang, X Lv, A Ghoshal, JW Dickerson, TM Bridges, ...
Neuron 86 (4), 1029-1040, 2015
Characterization of serotonin 5‐HT2C receptor signaling to extracellular signal‐regulated kinases 1 and 2
TD Werry, KJ Gregory, PM Sexton, A Christopoulos
Journal of neurochemistry 93 (6), 1603-1615, 2005
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity
JM Rook, MJ Noetzel, WA Pouliot, TM Bridges, PN Vinson, HP Cho, ...
Biological psychiatry 73 (6), 501-509, 2013
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor
K Leach, KJ Gregory, I Kufareva, E Khajehali, AE Cook, R Abagyan, ...
Cell research 26 (5), 574-592, 2016
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
AE Cook, SN Mistry, KJ Gregory, SGB Furness, PM Sexton, PJ Scammells, ...
British journal of pharmacology 172 (1), 185-200, 2015
Probing the metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a “molecular switch” in PAM …
KJ Gregory, ED Nguyen, SD Reiff, EF Squire, SR Stauffer, CW Lindsley, ...
Molecular pharmacology 83 (5), 991-1006, 2013
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling
MJ Noetzel, KJ Gregory, PN Vinson, JT Manka, SR Stauffer, CW Lindsley, ...
Molecular pharmacology 83 (4), 835-847, 2013
Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology
AS Hammond, AL Rodriguez, SD Townsend, CM Niswender, KJ Gregory, ...
ACS chemical neuroscience 1 (10), 702-716, 2010
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships
KJ Gregory, MJ Noetzel, JM Rook, PN Vinson, SR Stauffer, AL Rodriguez, ...
Molecular pharmacology 82 (5), 860-875, 2012
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