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Gopal Sapparapu
Gopal Sapparapu
Verified email at UCLA.edu
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Year
Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
G Sapparapu, E Fernandez, N Kose, B Cao, JM Fox, RG Bombardi, ...
Nature 540 (7633), 443-447, 2016
4102016
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
N Kose, JM Fox, G Sapparapu, R Bombardi, RN Tennekoon, AD De Silva, ...
Science immunology 4 (35), eaaw6647, 2019
1962019
Cross-neutralizing and protective human antibody specificities to poxvirus infections
I Gilchuk, P Gilchuk, G Sapparapu, R Lampley, V Singh, N Kose, DL Blum, ...
Cell 167 (3), 684-694. e9, 2016
1852016
Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection
AI Flyak, X Shen, CD Murin, HL Turner, JA David, ML Fusco, R Lampley, ...
Cell 164 (3), 392-405, 2016
1782016
Mechanism of human antibody-mediated neutralization of Marburg virus
AI Flyak, PA Ilinykh, CD Murin, T Garron, X Shen, ML Fusco, T Hashiguchi, ...
Cell 160 (5), 893-903, 2015
1652015
Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against chikungunya virus
SA Smith, LA Silva, JM Fox, AI Flyak, N Kose, G Sapparapu, ...
Cell host & microbe 18 (1), 86-95, 2015
1542015
A human antibody against Zika virus crosslinks the E protein to prevent infection
SS Hasan, A Miller, G Sapparapu, E Fernandez, T Klose, F Long, ...
Nature communications 8 (1), 14722, 2017
1512017
Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore
MS Aiyegbo, G Sapparapu, BW Spiller, IM Eli, DR Williams, R Kim, ...
PloS one 8 (5), e61101, 2013
932013
Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region
AI Flyak, N Kuzmina, CD Murin, C Bryan, E Davidson, P Gilchuk, ...
Nature microbiology 3 (6), 670-677, 2018
762018
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations
NJ Thornburg, H Zhang, S Bangaru, G Sapparapu, N Kose, RM Lampley, ...
The Journal of clinical investigation 126 (4), 1482-1494, 2016
702016
Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity
F Long, RH Fong, SK Austin, Z Chen, T Klose, A Fokine, Y Liu, J Porta, ...
Proceedings of the National Academy of Sciences 112 (45), 13898-13903, 2015
632015
Mapping the human memory B cell and serum neutralizing antibody responses to dengue virus serotype 4 infection and vaccination
UK Nivarthi, N Kose, G Sapparapu, D Widman, E Gallichotte, JM Pfaff, ...
Journal of virology 91 (5), 10.1128/jvi. 02041-16, 2017
622017
Dengue virus prM-specific human monoclonal antibodies with virus replication-enhancing properties recognize a single immunodominant antigenic site
SA Smith, UK Nivarthi, R de Alwis, N Kose, G Sapparapu, R Bombardi, ...
Journal of virology 90 (2), 780-789, 2016
592016
Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody
S Shanker, R Czakó, G Sapparapu, G Alvarado, M Viskovska, B Sankaran, ...
Proceedings of the National Academy of Sciences 113 (40), E5830-E5837, 2016
522016
Exceptional amyloid β peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffolds
H Taguchi, S Planque, G Sapparapu, S Boivin, M Hara, Y Nishiyama, ...
Journal of Biological Chemistry 283 (52), 36724-36733, 2008
472008
Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and …
IP Thomsen, G Sapparapu, DBA James, JE Cassat, M Nagarsheth, ...
The Journal of infectious diseases 215 (7), 1124-1131, 2017
432017
Mouse and human monoclonal antibodies protect against infection by multiple genotypes of Japanese encephalitis virus
E Fernandez, N Kose, MA Edeling, J Adhikari, G Sapparapu, SM Lazarte, ...
MBio 9 (1), 10.1128/mbio. 00008-18, 2018
382018
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses
NJ Thornburg, DP Nannemann, DL Blum, JA Belser, TM Tumpey, ...
The Journal of clinical investigation 123 (10), 4405-4409, 2013
352013
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth
JR Willis, G Sapparapu, S Murrell, JP Julien, V Singh, HG King, Y Xia, ...
The Journal of clinical investigation 125 (6), 2523-2531, 2015
342015
Frequent use of the IgA isotype in human B cells encoding potent norovirus-specific monoclonal antibodies that block HBGA binding
G Sapparapu, R Czakó, G Alvarado, S Shanker, BVV Prasad, RL Atmar, ...
PLoS Pathogens 12 (6), e1005719, 2016
322016
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