Ivanhoe Leung
Ivanhoe Leung
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The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ...
EMBO reports 12 (5), 463-469, 2011
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
TL Yeh, TM Leissing, MI Abboud, CC Thinnes, O Atasoylu, JP Holt-Martyn, ...
Chemical science 8 (11), 7651-7668, 2017
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
R Chowdhury, IKH Leung, YM Tian, MI Abboud, W Ge, C Domene, ...
Nature communications 7 (1), 12673, 2016
Structural and mechanistic studies on γ-butyrobetaine hydroxylase
IKH Leung, TJ Krojer, GT Kochan, L Henry, F von Delft, TDW Claridge, ...
Chemistry & biology 17 (12), 1316-1324, 2010
Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors
M Demetriades, IKH Leung, R Chowdhury, MC Chan, MA McDonough, ...
Angewandte Chemie International Edition 51 (27), 6672-6675, 2012
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
H Tarhonskaya, AM Rydzik, IKH Leung, ND Loik, MC Chan, A Kawamura, ...
Nature communications 5 (1), 3423, 2014
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation
JS Scotti, IKH Leung, W Ge, MA Bentley, J Paps, HB Kramer, J Lee, ...
Proceedings of the National Academy of Sciences 111 (37), 13331-13336, 2014
Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models
AL Zakharenko, OA Luzina, DN Sokolov, VI Kaledin, VP Nikolin, ...
European Journal of Medicinal Chemistry 161, 581-593, 2019
MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance
SJ Son, R Huang, CJ Squire, IKH Leung
Drug Discovery Today 24 (1), 206-216, 2019
Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
MC Chan, O Atasoylu, E Hodson, A Tumber, IKH Leung, R Chowdhury, ...
PLoS One 10 (7), e0132004, 2015
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors
IKH Leung, M Demetriades, AP Hardy, C Lejeune, TJ Smart, ...
Journal of medicinal chemistry 56 (2), 547-555, 2013
A photoreactive small-molecule probe for 2-oxoglutarate oxygenases
D Rotili, M Altun, A Kawamura, A Wolf, R Fischer, IKH Leung, ...
Chemistry & biology 18 (5), 642-654, 2011
Protein-directed dynamic combinatorial chemistry: a guide to protein ligand and inhibitor discovery
R Huang, IKH Leung
Molecules 21 (7), 910, 2016
Targeting isocitrate lyase for the treatment of latent tuberculosis
RP Bhusal, G Bashiri, BXC Kwai, J Sperry, IKH Leung
Drug discovery today 22 (7), 1008-1016, 2017
Protein-ligand binding affinity determination by the waterLOGSY method: an optimised approach considering ligand rebinding
R Huang, A Bonnichon, TDW Claridge, IKH Leung
Scientific Reports 7 (1), 43727, 2017
Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
H Tarhonskaya, R Chowdhury, IKH Leung, ND Loik, JSO McCullagh, ...
Biochemical Journal 463 (3), 363-372, 2014
Diphenylacetylene‐linked peptide strands induce bidirectional β‐sheet formation
H Lingard, JT Han, AL Thompson, IKH Leung, RTW Scott, S Thompson, ...
Angewandte Chemie International Edition 53 (14), 3650-3653, 2014
Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases
H Tarhonskaya, A Szöllössi, IKH Leung, JT Bush, L Henry, ...
Biochemistry 53 (15), 2483-2493, 2014
Substrate specificity of polyphenol oxidase
MA McLarin, IKH Leung
Critical Reviews in Biochemistry and Molecular Biology 55 (3), 274-308, 2020
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