mTOR is a key modulator of ageing and age-related disease SC Johnson, PS Rabinovitch, M Kaeberlein Nature 493 (7432), 338-345, 2013 | 2009 | 2013 |
Mitochondrial oxidative stress mediates angiotensin II–induced cardiac hypertrophy and Gαq overexpression–induced heart failure DF Dai, SC Johnson, JJ Villarin, MT Chin, M Nieves-Cintrón, T Chen, ... Circulation research 108 (7), 837-846, 2011 | 595 | 2011 |
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome SC Johnson, ME Yanos, EB Kayser, A Quintana, M Sangesland, ... Science 342 (6165), 1524-1528, 2013 | 555 | 2013 |
Targeted therapy in patients with PIK3CA-related overgrowth syndrome Q Venot, T Blanc, SH Rabia, L Berteloot, S Ladraa, JP Duong, E Blanc, ... Nature 558 (7711), 540-546, 2018 | 530 | 2018 |
Cardiac aging: from molecular mechanisms to significance in human health and disease DF Dai, T Chen, SC Johnson, H Szeto, PS Rabinovitch Antioxidants & redox signaling 16 (12), 1492-1526, 2012 | 376 | 2012 |
A comprehensive analysis of replicative lifespan in 4,698 single-gene deletion strains uncovers conserved mechanisms of aging MA McCormick, JR Delaney, M Tsuchiya, S Tsuchiyama, A Shemorry, ... Cell metabolism 22 (5), 895-906, 2015 | 265 | 2015 |
Molecular mechanisms underlying genotype‐dependent responses to dietary restriction J Schleit, SC Johnson, CF Bennett, M Simko, N Trongtham, A Castanza, ... Aging cell 12 (6), 1050-1061, 2013 | 180 | 2013 |
New generation of artificial MicroRNA and synthetic trans-acting small interfering RNA vectors for efficient gene silencing in Arabidopsis A Carbonell, A Takeda, N Fahlgren, SC Johnson, JT Cuperus, ... Plant physiology 165 (1), 15-29, 2014 | 160 | 2014 |
Modulating mTOR in aging and health SC Johnson, M Sangesland, M Kaeberlein, PS Rabinovitch Aging and health-A systems biology perspective 40, 107-127, 2015 | 113 | 2015 |
Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits A Teumer, Q Qi, M Nethander, H Aschard, S Bandinelli, M Beekman, ... Aging cell 15 (5), 811-824, 2016 | 101 | 2016 |
Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice SC Johnson, ME Yanos, A Bitto, A Castanza, A Gagnidze, B Gonzalez, ... Frontiers in genetics 6, 247, 2015 | 98 | 2015 |
Genetic evidence for common pathways in human age‐related diseases SC Johnson, X Dong, J Vijg, Y Suh Aging cell 14 (5), 809-817, 2015 | 94 | 2015 |
Nutrient sensing, signaling and ageing: the role of IGF-1 and mTOR in ageing and age-related disease SC Johnson Biochemistry and Cell Biology of Ageing: Part I Biomedical Science, 49-97, 2018 | 79 | 2018 |
Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy AH Kahn-Kirby, A Amagata, CI Maeder, JJ Mei, S Sideris, Y Kosaka, ... PLoS One 14 (3), e0214250, 2019 | 73 | 2019 |
Ex vivo imaging of excised tissue using vital dyes and confocal microscopy S Johnson, P Rabinovitch Current protocols in cytometry 61 (1), 9.39. 1-9.39. 18, 2012 | 72 | 2012 |
Mitochondrial pathways in human health and aging R Bornstein, B Gonzalez, SC Johnson Mitochondrion 54, 72-84, 2020 | 62 | 2020 |
Paracrine activation of hepatic stellate cells in platelet‐derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma JH Wright, MM Johnson, M Shimizu‐Albergine, RL Bauer, BJ Hayes, ... International journal of cancer 134 (4), 778-788, 2014 | 62 | 2014 |
Sir2 deletion prevents lifespan extension in 32 long‐lived mutants JR Delaney, GL Sutphin, B Dulken, S Sim, JR Kim, B Robison, J Schleit, ... Aging cell 10 (6), 1089-1091, 2011 | 60 | 2011 |
Rapamycin in aging and disease: maximizing efficacy while minimizing side effects SC Johnson, M Kaeberlein Oncotarget 7 (29), 44876, 2016 | 59 | 2016 |
mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases SC Johnson, F Martinez, A Bitto, B Gonzalez, C Tazaerslan, C Cohen, ... Kidney international 95 (2), 455-466, 2019 | 46 | 2019 |