David Higton
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Cassette dosing: rapid in vivo assessment of pharmacokinetics
LW Frick, KK Adkison, KJ Wells-Knecht, P Woollard, DM Higton
Pharmaceutical Science & Technology Today 1 (1), 12-18, 1998
Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review
RS Plumb, GJ Dear, DN Mallett, DM Higton, S Pleasance, ...
Xenobiotica 31 (8-9), 599-617, 2001
From definition to implementation: a cross-industry perspective of past, current and future MIST strategies
ANR Nedderman, GJ Dear, S North, RS Obach, D Higton
Xenobiotica 41 (8), 605-622, 2011
An investigation into the application of capillary electrochromatography-mass spectrometry (CEC-MS) for the analysis and quantification of a potential drug candidate in …
CJ Paterson, RJ Boughtflower, D Higton, E Palmer
Chromatographia 46 (11), 599-604, 1997
European Bioanalysis Forum recommendation: scientific validation of quantification by accelerator mass spectrometry
D Higton, G Young, P Timmerman, R Abbott, M Knutsson, LD Svensson
Bioanalysis 4 (22), 2669-2679, 2012
Determination of 4‐hydroxytamoxifen in mouse plasma in the pg/mL range by gradient capillary liquid chromatography/tandem mass spectrometry
RS Plumb, H Warwick, D Higton, GJ Dear, DN Mallett
Rapid Communications in Mass Spectrometry 15 (4), 297-303, 2001
AMS method validation for quantitation in pharmacokinetic studies with concomitant extravascular and intravenous administration
G Lappin, M Seymour, G Young, D Higton, HM Hill
Bioanalysis 3 (4), 393-405, 2011
Ask the experts: automation: part I.
JL Allinson, KE Blick, L Cohen, D Higton, M Li
Bioanalysis 5 (16), 1953-1962, 2013
The potential of serially coupled alkyl-bonded silica monolithic columns for high resolution separations of pharmaceutical compounds in biological fluids
GJ Dear, DN Mallett, DM Higton, AD Roberts, SA Bird, H Young, ...
Chromatographia 55 (3), 177-184, 2002
Absorption and disposition of ranitidine hydrochloride in rat and dog
PJ Eddershaw, AP Chadwick, DM Higton, SH Fenwick, P Linacre, ...
Xenobiotica 26 (9), 947-956, 1996
Use of cyclic ion mobility spectrometry (cIM)-mass spectrometry to study the intramolecular transacylation of diclofenac acyl glucuronide
D Higton, ME Palmer, JPC Vissers, LG Mullin, RS Plumb, ID Wilson
Analytical Chemistry 93 (20), 7413-7421, 2021
Cassette dosing: rapid estimation of in vivo pharmacokinetics
LW Frick
Med. Chem. Res. 8, 472-477, 1998
A rapid, automated approach to optimisation of multiple reaction monitoring conditions for quantitative bioanalytical mass spectrometry
DM Higton
Rapid Communications in Mass Spectrometry 15 (20), 1922-1930, 2001
An AMS method to determine analyte recovery from pharmacokinetic studies with concomitant extravascular and intravenous administration
G Lappin, M Seymour, G Young, D Higton, HM Hill
Bioanalysis 3 (4), 407-410, 2011
Investigation into Small Molecule Isomeric Glucuronide Metabolite Differentiation Using In Silico and Experimental Collision Cross-Section Values
JRFB Connolly, J Munoz-Muriedas, C Lapthorn, D Higton, JPC Vissers, ...
Journal of the American Society for Mass Spectrometry 32 (8), 1976-1986, 2021
Mass spectrometry: pharmaceutical sciences
DM Higton, JM Oxford
Applied Spectroscopy Reviews 30 (1-2), 81-118, 1995
Thermospray liquid chromatography-mass spectrometry for the characterization of sulphate ester conjugates
GD Bowers, DM Higton, GR Manchee, J Oxford, DA Saynor
Journal of Chromatography A 554 (1-2), 175-180, 1991
Conference Report: Drug Metabolism Discussion Group Short Meeting: microsampling–the next big thing
K Jackson-Addie, K Woods, A Muir, C Smith, D Higton
Regulatory Toxicology and Pharmacology 73 (1), 2024
Fundamental aspects of mass spectrometry
MV Doig, DM Higton
Principles and practice of bioanalysis. 2nd ed. Boca Raton: Taulor & Francis …, 2008
Application of a tiered approach to the validation of accelerator MS assays
D Higton, M Seymour
Bioanalysis 6 (5), 665-672, 2014
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