| Tuberculosis: the drug development pipeline at a glance B Villemagne, C Crauste, M Flipo, AR Baulard, B Déprez, N Willand European journal of medicinal chemistry 51, 1-16, 2012 | 256 | 2012 |
| Synthetic EthR inhibitors boost antituberculous activity of ethionamide N Willand, B Dirie, X Carette, P Bifani, A Singhal, M Desroses, F Leroux, ... Nature medicine 15 (5), 537-544, 2009 | 214 | 2009 |
| Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 N Blondiaux, M Moune, M Desroses, R Frita, M Flipo, V Mathys, ... Science 355 (6330), 1206-1211, 2017 | 139 | 2017 |
| Natural compounds: leads or ideas? Bioinspired molecules for drug discovery T Beghyn, R Deprez‐Poulain, N Willand, B Folleas, B Deprez Chemical biology & drug design 72 (1), 3-15, 2008 | 120 | 2008 |
| Ethionamide boosters: synthesis, biological activity, and structure− activity relationships of a series of 1, 2, 4-oxadiazole EthR inhibitors M Flipo, M Desroses, N Lecat-Guillet, B Dirié, X Carette, F Leroux, ... Journal of Medicinal Chemistry 54 (8), 2994-3010, 2011 | 110 | 2011 |
| Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles J Costa-Gouveia, E Pancani, S Jouny, A Machelart, V Delorme, ... Scientific reports 7 (1), 5390, 2017 | 100 | 2017 |
| Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1, 2, 4-oxadiazole EthR inhibitors M Flipo, M Desroses, N Lecat-Guillet, B Villemagne, N Blondiaux, ... Journal of medicinal chemistry 55 (1), 68-83, 2012 | 93 | 2012 |
| Exploring Drug Target Flexibility Using in Situ Click Chemistry: Application to a Mycobacterial Transcriptional Regulator N Willand, M Desroses, P Toto, B Dirie, Z Lens, V Villeret, P Rucktooa, ... ACS Chemical Biology 5 (11), 1007-1013, 2010 | 91 | 2010 |
| Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking … B Villemagne, M Flipo, N Blondiaux, C Crauste, S Malaquin, F Leroux, ... Journal of medicinal chemistry 57 (11), 4876-4888, 2014 | 73 | 2014 |
| Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis M Flipo, N Willand, N Lecat-Guillet, C Hounsou, M Desroses, F Leroux, ... Journal of medicinal chemistry 55 (14), 6391-6402, 2012 | 54 | 2012 |
| Intrinsic antibacterial activity of nanoparticles made of β-cyclodextrins potentiates their effect as drug nanocarriers against tuberculosis A Machelart, G Salzano, X Li, A Demars, AS Debrie, ... ACS nano 13 (4), 3992-4007, 2019 | 46 | 2019 |
| Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands X Carette, N Blondiaux, E Willery, S Hoos, N Lecat-Guillet, Z Lens, ... Nucleic acids research 40 (7), 3018-3030, 2012 | 40 | 2012 |
| Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery NC Tran, H Dhondt, M Flipo, B Deprez, N Willand Tetrahedron letters 56 (27), 4119-4123, 2015 | 38 | 2015 |
| Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps C Plé, HK Tam, A Vieira Da Cruz, N Compagne, JC Jiménez-Castellanos, ... Nature Communications 13 (1), 115, 2022 | 35 | 2022 |
| Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs G Salzano, J Wankar, S Ottani, B Villemagne, AR Baulard, N Willand, ... International Journal of Pharmaceutics 531 (2), 577-587, 2017 | 33 | 2017 |
| MALDI imaging techniques dedicated to drug-distribution studies D Bonnel, R Legouffe, N Willand, A Baulard, G Hamm, B Deprez, ... Bioanalysis 3 (12), 1399-1406, 2011 | 33 | 2011 |
| A facile and rapid synthesis of N-benzyl-2-substituted piperazines M Jida, M Soueidan, N Willand, F Agbossou-Niedercorn, L Pelinski, ... Tetrahedron letters 52 (14), 1705-1708, 2011 | 33 | 2011 |
| Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space H Prevet, M Flipo, P Roussel, B Deprez, N Willand Tetrahedron Letters 57 (26), 2888-2894, 2016 | 32 | 2016 |
| UFU (‘Ullmann–Finkelstein–Ullmann’): a new multicomponent reaction P Toto, JC Gesquière, N Cousaert, B Deprez, N Willand Tetrahedron letters 47 (28), 4973-4978, 2006 | 31 | 2006 |
| New active leads for tuberculosis booster drugs by structure-based drug discovery NJ Tatum, JW Liebeschuetz, JC Cole, R Frita, A Herledan, AR Baulard, ... Organic & Biomolecular Chemistry 15 (48), 10245-10255, 2017 | 29 | 2017 |
