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Nicholas Levinson
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A Src-like inactive conformation in the abl tyrosine kinase domain
NM Levinson, O Kuchment, K Shen, MA Young, M Koldobskiy, M Karplus, ...
PLoS biology 4 (5), e144, 2006
3562006
A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity
NM Levinson, SG Boxer
Nature chemical biology 10 (2), 127-132, 2014
1662014
Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain
NM Levinson, SG Boxer
PloS one 7 (4), e29828, 2012
1542012
Structural basis for the recognition of c-Src by its inactivator Csk
NM Levinson, MA Seeliger, PA Cole, J Kuriyan
Cell 134 (1), 124-134, 2008
1492008
Experimental quantification of electrostatics in X–Hˇˇˇ π hydrogen bonds
M Saggu, NM Levinson, SG Boxer
Journal of the American Chemical Society 134 (46), 18986-18997, 2012
1312012
Solvent-induced infrared frequency shifts in aromatic nitriles are quantitatively described by the vibrational Stark effect
NM Levinson, SD Fried, SG Boxer
The journal of physical chemistry B 116 (35), 10470-10476, 2012
1262012
Direct measurements of electric fields in weak OHˇˇˇ π hydrogen bonds
M Saggu, NM Levinson, SG Boxer
Journal of the American Chemical Society 133 (43), 17414-17419, 2011
1222011
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
EF Ruff, JM Muretta, AR Thompson, EW Lake, S Cyphers, SK Albanese, ...
Elife 7, e32766, 2018
642018
A water-mediated allosteric network governs activation of Aurora kinase A
S Cyphers, EF Ruff, JM Behr, JD Chodera, NM Levinson
Nature chemical biology 13 (4), 402-408, 2017
622017
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
EW Lake, JM Muretta, AR Thompson, DM Rasmussen, A Majumdar, ...
Proceedings of the National Academy of Sciences 115 (51), E11894-E11903, 2018
582018
The multifaceted allosteric regulation of Aurora kinase A
NM Levinson
Biochemical Journal 475 (12), 2025-2042, 2018
562018
Phosphate vibrations probe local electric fields and hydration in biomolecules
NM Levinson, EE Bolte, CS Miller, SA Corcelli, SG Boxer
Journal of the American Chemical Society 133 (34), 13236-13239, 2011
522011
An open library of human kinase domain constructs for automated bacterial expression
SK Albanese, DL Parton, M Işık, L Rodríguez-Laureano, SM Hanson, ...
Biochemistry 57 (31), 4675-4689, 2018
472018
The tyrosine kinase Csk dimerizes through Its SH3 domain
NM Levinson, PR Visperas, J Kuriyan
PloS one 4 (11), e7683, 2009
322009
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry
N Tavernier, Y Thomas, S Vigneron, P Maisonneuve, S Orlicky, P Mader, ...
Nature communications 12 (1), 1899, 2021
232021
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors
A Majumdar, DJ Burban, JM Muretta, AR Thompson, TA Engel, ...
Nature chemical biology 17 (4), 456-464, 2021
222021
The pseudokinase domains of guanylyl cyclase–A and–B allosterically increase the affinity of their catalytic domains for substrate
AB Edmund, TF Walseth, NM Levinson, LR Potter
Science signaling 12 (566), eaau5378, 2019
152019
Cooperativity between orthosteric inhibitors and allosteric inhibitor 8-anilino-1-naphthalene sulfonic acid (ANS) in cyclin-dependent kinase 2
EB Faber, D Tian, D Burban, NM Levinson, JE Hawkinson, GI Georg
ACS chemical biology 15 (7), 1759-1764, 2020
132020
Screening through lead optimization of high affinity, allosteric cyclin-dependent kinase 2 (CDK2) inhibitors as male contraceptives that reduce sperm counts in mice
EB Faber, N Wang, K John, L Sun, HL Wong, D Burban, R Francis, D Tian, ...
Journal of medicinal chemistry 66 (3), 1928-1940, 2023
112023
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
EB Faber, L Sun, J Tang, E Roberts, S Ganeshkumar, N Wang, ...
Nature communications 14 (1), 3213, 2023
102023
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