Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy CX Dominguez, S Müller, S Keerthivasan, H Koeppen, J Hung, S Gierke, ... Cancer discovery 10 (2), 232-253, 2020 | 530 | 2020 |
USP7 small-molecule inhibitors interfere with ubiquitin binding L Kategaya, P Di Lello, L Rougé, R Pastor, KR Clark, J Drummond, ... Nature 550 (7677), 534-538, 2017 | 283 | 2017 |
Effector-attenuating substitutions that maintain antibody stability and reduce toxicity in mice M Lo, HS Kim, RK Tong, TW Bainbridge, JM Vernes, Y Zhang, YL Lin, ... Journal of Biological Chemistry 292 (9), 3900-3908, 2017 | 258 | 2017 |
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function EE Storm, S Durinck, F de Sousa E Melo, J Tremayne, N Kljavin, C Tan, ... Nature 529 (7584), 97-100, 2016 | 232 | 2016 |
Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein JA Maloney, T Bainbridge, A Gustafson, S Zhang, R Kyauk, P Steiner, ... Journal of Biological Chemistry 289 (45), 30990-31000, 2014 | 212 | 2014 |
Fibroblast activation protein cleaves and inactivates fibroblast growth factor 21 DR Dunshee, TW Bainbridge, NM Kljavin, J Zavala-Solorio, ... Journal of Biological Chemistry 291 (11), 5986-5996, 2016 | 143 | 2016 |
Structure of crenezumab complex with Aβ shows loss of β-hairpin M Ultsch, B Li, T Maurer, M Mathieu, O Adolfsson, A Muhs, A Pfeifer, ... Scientific reports 6 (1), 39374, 2016 | 116 | 2016 |
Sustained brown fat stimulation and insulin sensitization by a humanized bispecific antibody agonist for fibroblast growth factor receptor 1/βKlotho complex G Kolumam, MZ Chen, R Tong, J Zavala-Solorio, L Kates, N van Bruggen, ... EBioMedicine 2 (7), 730-743, 2015 | 109 | 2015 |
Molecular understanding of USP7 substrate recognition and C-terminal activation L Rougé, TW Bainbridge, M Kwok, R Tong, P Di Lello, IE Wertz, T Maurer, ... Structure 24 (8), 1335-1345, 2016 | 93 | 2016 |
Evolutionary Divergence in the Catalytic Activity of the CAM-1, ROR1 and ROR2 Kinase Domains TW Bainbridge, VI DeAlmeida, A Izrael-Tomasevic, C Chalouni, B Pan, ... PloS one 9 (7), e102695, 2014 | 46 | 2014 |
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage CB Cox, EE Storm, VN Kapoor, J Chavarria-Smith, DL Lin, L Wang, Y Li, ... Science Immunology 6 (59), eabe8856, 2021 | 37 | 2021 |
Selective homogeneous assay for circulating endopeptidase fibroblast activation protein (FAP) TW Bainbridge, DR Dunshee, NM Kljavin, NJ Skelton, J Sonoda, JA Ernst Scientific Reports 7 (1), 12524, 2017 | 32 | 2017 |
Vaccinia H5 is a multifunctional protein involved in viral DNA replication, postreplicative gene transcription, and virion morphogenesis SM D'Costa, TW Bainbridge, SE Kato, C Prins, K Kelley, RC Condit Virology 401 (1), 49-60, 2010 | 30 | 2010 |
Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ WJ Meilandt, JA Maloney, J Imperio, G Lalehzadeh, T Earr, S Crowell, ... Alzheimer's research & therapy 11, 1-14, 2019 | 26 | 2019 |
Marker rescue mapping of the combined Condit/Dales collection of temperature-sensitive vaccinia virus mutants SEM Kato, N Moussatche, SM D'Costa, TW Bainbridge, C Prins, AL Strahl, ... Virology 375 (1), 213-222, 2008 | 26 | 2008 |
Purification and properties of the vaccinia virus mRNA processing factor SM D'Costa, TW Bainbridge, RC Condit Journal of biological chemistry 283 (9), 5267-5275, 2008 | 17 | 2008 |
Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy JC Chang, S Durinck, MZ Chen, N Martinez-Martin, JA Zhang, I Lehoux, ... Scientific Reports 9 (1), 8833, 2019 | 15 | 2019 |
Biochemical and biophysical properties of a putative hub protein expressed by vaccinia virus NE Kay, TW Bainbridge, RC Condit, MR Bubb, RE Judd, ... Journal of Biological Chemistry 288 (16), 11470-11481, 2013 | 11 | 2013 |
Characterization of the selective in vivo and in vitro binding properties of crenezumab: insights into crenezumab’s unique mechanism of action (P6. 174) W Meilandt, J Maloney, J Imperio, T Bainbridge, M Reichelt, D Mandikian, ... Neurology 90 (15 Supplement), 2018 | 5 | 2018 |
Crenezumab’s Preferential Binding Of Oligomeric Amyloid-Beta Species Underlies Its Unique Mechanism Of Action (S7. 005) J Atwal, W Meilandt, M Wetzel-Smith, B Li, T Bainbridge, M Reichelt, ... Neurology 88 (16 Supplement), 2017 | 3 | 2017 |