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Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming β structure M Von Bergen, P Friedhoff, J Biernat, J Heberle, EM Mandelkow, ... Proceedings of the National Academy of Sciences 97 (10), 5129-5134, 2000 | 1215 | 2000 |
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease JC Augustinack, A Schneider, EM Mandelkow, BT Hyman Acta neuropathologica 103, 26-35, 2002 | 1200 | 2002 |
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress K Stamer, R Vogel, E Thies, E Mandelkow, EM Mandelkow The Journal of cell biology 156 (6), 1051-1063, 2002 | 1105 | 2002 |
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption G Drewes, A Ebneth, U Preuss, EM Mandelkow, E Mandelkow Cell 89 (2), 297-308, 1997 | 1056 | 1997 |
Biochemistry and cell biology of tau protein in neurofibrillary degeneration EM Mandelkow, E Mandelkow Cold Spring Harbor perspectives in medicine 2 (7), a006247, 2012 | 1045 | 2012 |
Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease A Ebneth, R Godemann, K Stamer, S Illenberger, B Trinczek, ... The Journal of cell biology 143 (3), 777-794, 1998 | 1026 | 1998 |
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding J Biernat, N Gustke, G Drewes, E Mandelkow Neuron 11 (1), 153-163, 1993 | 1013 | 1993 |
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads F Braak, H Braak, EM Mandelkow Acta neuropathologica 87, 554-567, 1994 | 996 | 1994 |
Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease: A PROPERTY COMMON TO MOST … S Leclerc, M Garnier, R Hoessel, D Marko, JA Bibb, GL Snyder, ... Journal of Biological Chemistry 276 (1), 251-260, 2001 | 955 | 2001 |
Aβ oligomers cause localized Ca2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines H Zempel, E Thies, E Mandelkow, EM Mandelkow Journal of Neuroscience 30 (36), 11938-11950, 2010 | 828 | 2010 |
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Tau in Alzheimer's disease EM Mandelkow, E Mandelkow Trends in cell biology 8 (11), 425-427, 1998 | 776 | 1998 |
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer‐like state. G Drewes, B Lichtenberg‐Kraag, F Döring, EM Mandelkow, J Biernat, ... The EMBO journal 11 (6), 2131-2138, 1992 | 771 | 1992 |
Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study. EM Mandelkow, E Mandelkow, RA Milligan The Journal of cell biology 114 (5), 977-991, 1991 | 751 | 1991 |
Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau EM Mandelkow, G Drewes, J Biernat, N Gustke, J Van Lint, ... FEBS letters 314 (3), 315-321, 1992 | 724 | 1992 |
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing Y Wang, M Martinez-Vicente, U Krüger, S Kaushik, E Wong, ... Human molecular genetics 18 (21), 4153-4170, 2009 | 701 | 2009 |
The release and trans-synaptic transmission of Tau via exosomes Y Wang, V Balaji, S Kaniyappan, L Krüger, S Irsen, K Tepper, ... Molecular neurodegeneration 12, 1-25, 2017 | 695 | 2017 |
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local β-structure M Von Bergen, S Barghorn, L Li, A Marx, J Biernat, EM Mandelkow, ... Journal of Biological Chemistry 276 (51), 48165-48174, 2001 | 690 | 2001 |
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments A Schneider, J Biernat, M Von Bergen, E Mandelkow, EM Mandelkow Biochemistry 38 (12), 3549-3558, 1999 | 677 | 1999 |