| Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase SI Imai, CM Armstrong, M Kaeberlein, L Guarente Nature 403 (6771), 795-800, 2000 | 4314 | 2000 |
| The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms M Kaeberlein, M McVey, L Guarente Genes & development 13 (19), 2570-2580, 1999 | 2803 | 1999 |
| mTOR is a key modulator of ageing and age-related disease SC Johnson, PS Rabinovitch, M Kaeberlein Nature 493 (7432), 338-345, 2013 | 2001 | 2013 |
| Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients M Kaeberlein, RW Powers III, KK Steffen, EA Westman, D Hu, N Dang, ... Science 310 (5751), 1193-1196, 2005 | 1586 | 2005 |
| Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration SJ Lin, M Kaeberlein, AA Andalis, LA Sturtz, PA Defossez, VC Culotta, ... Nature 418 (6895), 344-348, 2002 | 1323 | 2002 |
| Extension of chronological life span in yeast by decreased TOR pathway signaling RW Powers, M Kaeberlein, SD Caldwell, BK Kennedy, S Fields Genes & development 20 (2), 174-184, 2006 | 1203 | 2006 |
| Substrate-specific activation of sirtuins by resveratrol M Kaeberlein, T McDonagh, B Heltweg, J Hixon, EA Westman, ... Journal of Biological Chemistry 280 (17), 17038-17045, 2005 | 942 | 2005 |
| Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila C Burnett, S Valentini, F Cabreiro, M Goss, M Somogyvári, MD Piper, ... nature 477 (7365), 482-485, 2011 | 770 | 2011 |
| Histone H4 lysine 16 acetylation regulates cellular lifespan W Dang, KK Steffen, R Perry, JA Dorsey, FB Johnson, A Shilatifard, ... Nature 459 (7248), 802-807, 2009 | 748 | 2009 |
| Replicative and chronological aging in Saccharomyces cerevisiae VD Longo, GS Shadel, M Kaeberlein, B Kennedy Cell metabolism 16 (1), 18-31, 2012 | 702 | 2012 |
| mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome SC Johnson, ME Yanos, EB Kayser, A Quintana, M Sangesland, ... Science 342 (6165), 1524-1528, 2013 | 554 | 2013 |
| Sir2-independent life span extension by calorie restriction in yeast M Kaeberlein, KT Kirkland, S Fields, BK Kennedy PLoS biology 2 (9), e296, 2004 | 540 | 2004 |
| Lessons on longevity from budding yeast M Kaeberlein Nature 464 (7288), 513-519, 2010 | 537 | 2010 |
| Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4 KK Steffen, VL MacKay, EO Kerr, M Tsuchiya, D Hu, LA Fox, N Dang, ... Cell 133 (2), 292-302, 2008 | 518 | 2008 |
| The TOR pathway comes of age MN Stanfel, LS Shamieh, M Kaeberlein, BK Kennedy Biochimica et Biophysica Acta (BBA)-General Subjects 1790 (10), 1067-1074, 2009 | 515 | 2009 |
| Elimination of replication block protein Fob1 extends the life span of yeast mother cells PA Defossez, R Prusty, M Kaeberlein, SJ Lin, P Ferrigno, PA Silver, ... Molecular cell 3 (4), 447-455, 1999 | 481 | 1999 |
| Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice A Bitto, TK Ito, VV Pineda, NJ LeTexier, HZ Huang, E Sutlief, H Tung, ... elife 5, e16351, 2016 | 441 | 2016 |
| A molecular mechanism of chronological aging in yeast CR Burtner, CJ Murakami, BK Kennedy, M Kaeberlein Cell cycle 8 (8), 1256-1270, 2009 | 428 | 2009 |
| Lifespan extension in Caenorhabditis elegans by complete removal of food TL Kaeberlein, ED Smith, M Tsuchiya, KL Welton, JH Thomas, S Fields, ... Aging cell 5 (6), 487-494, 2006 | 388 | 2006 |
| Rapamycin reverses elevated mTORC1 signaling in lamin A/C–deficient mice, rescues cardiac and skeletal muscle function, and extends survival FJ Ramos, SC Chen, MG Garelick, DF Dai, CY Liao, KH Schreiber, ... Science translational medicine 4 (144), 144ra103-144ra103, 2012 | 385 | 2012 |
