Alejandro Couce
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Antibiotics and antibiotic resistance: a bitter fight against evolution
A Rodríguez-Rojas, J Rodríguez-Beltrán, A Couce, J Blázquez
International Journal of Medical Microbiology 303 (6-7), 293-297, 2013
Antimicrobials as promoters of genetic variation
J Blázquez, A Couce, J Rodríguez-Beltrán, A Rodríguez-Rojas
Current opinion in microbiology 15 (5), 561-569, 2012
Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials
TD Thi, E López, A Rodríguez-Rojas, J Rodríguez-Beltrán, A Couce, ...
Journal of Antimicrobial Chemotherapy 66 (3), 531-538, 2011
Side effects of antibiotics on genetic variability
A Couce, J Blázquez
FEMS microbiology reviews 33 (3), 531-538, 2009
Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria
A Couce, LV Caudwell, C Feinauer, T Hindré, JP Feugeas, M Weigt, ...
Proceedings of the National Academy of Sciences 114 (43), E9026-E9035, 2017
The rule of declining adaptability in microbial evolution experiments
A Couce, OA Tenaillon
Frontiers in genetics 6, 128797, 2015
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: MurA confers clinical resistance at low fitness cost
A Couce, A Briales, A Rodríguez-Rojas, C Costas, Á Pascual, J Blázquez
Antimicrobial agents and chemotherapy 56 (5), 2767-2769, 2012
The Escherichia coli SOS Gene dinF Protects against Oxidative Stress and Bile Salts
J Rodríguez-Beltrán, A Rodriguez-Rojas, JR Guelfo, A Couce, J Blazquez
PloS one 7 (4), e34791, 2012
Mutational spectrum drives the rise of mutator bacteria
A Couce, JR Guelfo, J Blázquez
PLoS genetics 9 (1), e1003167, 2013
Assessing the Emergence of Resistance: The Absence of Biological Cost In Vivo May Compromise Fosfomycin Treatments for P. aeruginosa Infections
A Rodriguez-Rojas, MD Macia, A Couce, C Gomez, A Castaneda-Garcia, ...
PLoS One 5 (4), e10193, 2010
Bypass of genetic constraints during mutator evolution to antibiotic resistance
A Couce, A Rodríguez-Rojas, J Blázquez
Proceedings of the Royal Society B: Biological Sciences 282 (1804), 20142698, 2015
Parallel evolution of high-level aminoglycoside resistance in Escherichia coli under low and high mutation supply rates
C Ibacache-Quiroga, JC Oliveros, A Couce, J Blázquez
Frontiers in microbiology 9, 310259, 2018
Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway
H Kemble, C Eisenhauer, A Couce, A Chapron, M Magnan, G Gautier, ...
Science Advances 6 (23), eabb2236, 2020
Frequency of Spontaneous Resistance to Fosfomycin Combined with Different Antibiotics in Pseudomonas aeruginosa
A Rodríguez-Rojas, A Couce, J Blázquez
Antimicrobial agents and chemotherapy 54 (11), 4948-4949, 2010
Mutation bias and GC content shape antimutator invasions
A Couce, O Tenaillon
Nature communications 10 (1), 1-9, 2019
Intrapopulation variability in mutator prevalence among urinary tract infection isolates of Escherichia coli
A Couce, N Alonso-Rodriguez, C Costas, A Oliver, J Blázquez
Clinical Microbiology and Infection 22 (6), 566. e1-566. e7, 2016
Estimating mutation rates in low-replication experiments
A Couce, J Blázquez
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 714 (1 …, 2011
Predictability shifts from local to global rules during bacterial adaptation
A Couce, M Magnan, RE Lenski, O Tenaillon
bioRxiv, 2022.05.17.492360, 2022
Determinants of genetic diversity of spontaneous drug resistance in bacteria
A Couce, A Rodríguez-Rojas, J Blázquez
Genetics 203 (3), 1369-1380, 2016
Changing fitness effects of mutations through long-term bacterial evolution
A Couce, A Limdi, M Magnan, SV Owen, CM Herren, RE Lenski, ...
Science 383 (6681), eadd1417, 2024
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