Matthew A. Young
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Structural basis for the autoinhibition of c-Abl tyrosine kinase
B Nagar, O Hantschel, MA Young, K Scheffzek, D Veach, W Bornmann, ...
Cell 112 (6), 859-871, 2003
Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation
MA Young, S Gonfloni, G Superti-Furga, B Roux, J Kuriyan
Cell 105 (1), 115-126, 2001
Intrusion of counterions into the spine of hydration in the minor groove of B-DNA: fractional occupancy of electronegative pockets
MA Young, B Jayaram, DL Beveridge
Journal of the American Chemical Society 119 (1), 59-69, 1997
Molecular dynamics simulation of nucleic acids: successes, limitations, and promise
TE Cheatham III, MA Young
Biopolymers: Original Research on Biomolecules 56 (4), 232-256, 2000
A Src-like inactive conformation in the abl tyrosine kinase domain
NM Levinson, O Kuchment, K Shen, MA Young, M Koldobskiy, M Karplus, ...
PLoS biology 4 (5), e144, 2006
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680
MA Young, NP Shah, LH Chao, M Seeliger, ZV Milanov, WH Biggs III, ...
Cancer research 66 (2), 1007-1014, 2006
A 5-nanosecond molecular dynamics trajectory for B-DNA: analysis of structure, motions, and solvation
MA Young, G Ravishanker, DL Beveridge
Biophysical Journal 73 (5), 2313-2336, 1997
Molecular dynamics simulations of the 136 unique tetranucleotide sequences of DNA oligonucleotides. I. Research design and results on d (CpG) steps
DL Beveridge, G Barreiro, KS Byun, DA Case, TE Cheatham, SB Dixit, ...
Biophysical journal 87 (6), 3799-3813, 2004
Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III
D Jeruzalmi, O Yurieva, Y Zhao, M Young, J Stewart, M Hingorani, ...
Cell 106 (4), 417-428, 2001
High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases
MA Seeliger, M Young, MN Henderson, P Pellicena, DS King, AM Falick, ...
Protein Science 14 (12), 3135-3139, 2005
Free energy analysis of the conformational preferences of A and B forms of DNA in solution
B Jayaram, D Sprous, MA Young, DL Beveridge
Journal of the American Chemical Society 120 (41), 10629-10633, 1998
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases
D Wisniewski, CL Lambek, C Liu, A Strife, DR Veach, B Nagar, MA Young, ...
Cancer research 62 (15), 4244-4255, 2002
Emerging potential of therapeutic targeting of ubiquitin-specific proteases in the treatment of cancer
A Pal, MA Young, NJ Donato
Cancer research 74 (18), 4955-4966, 2014
Local dielectric environment of B-DNA in solution: Results from a 14 ns molecular dynamics trajectory
MA Young, B Jayaram, DL Beveridge
The Journal of Physical Chemistry B 102 (39), 7666-7669, 1998
Molecular dynamics simulations of an oligonucleotide duplex with adenine tracts phased by a full helix turn
MA Young, DL Beveridge
Journal of molecular biology 281 (4), 675-687, 1998
Analysis of local helix bending in crystal structures of DNA oligonucleotides and DNA-protein complexes
MA Young, G Ravishanker, DL Beveridge, HM Berman
Biophysical journal 68 (6), 2454-2468, 1995
Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies
LF Peterson, H Sun, Y Liu, H Potu, M Kandarpa, M Ermann, SM Courtney, ...
Blood, The Journal of the American Society of Hematology 125 (23), 3588-3597, 2015
Transcription factor binding to a DNA zip code controls interchromosomal clustering at the nuclear periphery
DG Brickner, S Ahmed, L Meldi, A Thompson, W Light, M Young, ...
Developmental cell 22 (6), 1234-1246, 2012
Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis
ZQ Bao, DM Jacobsen, MA Young
Structure 19 (5), 675-690, 2011
Molecular dynamics studies of axis bending in d (G5-(GA4T4C) 2-C5) and d (G5-(GT4A4C) 2-C5): effects of sequence polarity on DNA curvature
D Sprous, MA Young, DL Beveridge
Journal of molecular biology 285 (4), 1623-1632, 1999
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