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Eric Josephs
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Increasing the specificity of CRISPR systems with engineered RNA secondary structures
DD Kocak, EA Josephs, V Bhandarkar, SS Adkar, JB Kwon, CA Gersbach
Nature biotechnology 37 (6), 657-666, 2019
3142019
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage
EA Josephs, DD Kocak, CJ Fitzgibbon, J McMenemy, CA Gersbach, ...
Nucleic acids research 43 (18), 8924-8941, 2015
1552015
Nanoscale spatial distribution of thiolated DNA on model nucleic acid sensor surfaces
EA Josephs, T Ye
ACS nano 7 (4), 3653-3660, 2013
862013
A single-molecule view of conformational switching of DNA tethered to a gold electrode
EA Josephs, T Ye
Journal of the American Chemical Society 134 (24), 10021-10030, 2012
822012
Electric-field dependent conformations of single DNA molecules on a model biosensor surface
EA Josephs, T Ye
Nano letters 12 (10), 5255-5261, 2012
452012
A switchable surface enables visualization of single DNA hybridization events with atomic force microscopy
GR Abel Jr, EA Josephs, N Luong, T Ye
Journal of the American Chemical Society 135 (17), 6399-6402, 2013
362013
Nanoscale positioning of individual DNA molecules by an atomic force microscope
EA Josephs, T Ye
Journal of the American Chemical Society 132 (30), 10236-10238, 2010
362010
Electrochemical etching of gold within nanoshaved self-assembled monolayers
J Shao, EA Josephs, C Lee, A Lopez, T Ye
ACS nano 7 (6), 5421-5429, 2013
242013
Nanoscale chemical patterns on gold microplates
C Lee, EA Josephs, J Shao, T Ye
The Journal of Physical Chemistry C 116 (33), 17625-17632, 2012
182012
Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair
EA Josephs, T Zheng, PE Marszalek
DNA repair 35, 71-84, 2015
172015
Modular, nondegenerate polyprotein scaffolds for atomic force spectroscopy
ZN Scholl, EA Josephs, PE Marszalek
Biomacromolecules 17 (7), 2502-2505, 2016
142016
Compositions and methods of improving specificity in genomic engineering using RNA-guided endonucleases
E Josephs, D Kocak, P Marszalek, CA Gersbach
US Patent 11,427,817, 2022
8*2022
Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope
ZN Scholl, Q Li, E Josephs, D Apostolidou, PE Marszalek
JoVE (Journal of Visualized Experiments), e55989, 2019
82019
Molecular conformations of DNA targets captured by model nanoarrays
X Hao, EA Josephs, Q Gu, T Ye
Nanoscale 9 (36), 13419-13424, 2017
82017
Polyvalent guide RNAs for CRISPR antivirals
R Bagchi, R Tinker-Kulberg, M Salehin, T Supakar, S Chamberlain, ...
iScience 25 (11), 105333, 2022
72022
Hybridization and self‐assembly behaviors of surface‐immobilized DNA in close proximity: A single‐molecule perspective
Q Gu, EA Josephs, T Ye
Aggregate, e186, 2022
72022
Digital data storage on DNA tape using CRISPR base editors
A Sadremomtaz, RF Glass, JE Guerrero, DR LaJeunesse, EA Josephs, ...
Nature Communications 14 (1), 6472, 2023
62023
Toward a Quantitative Relationship between Nanoscale Spatial Organization and Hybridization Kinetics of Surface Immobilized Hairpin DNA Probes
Q Gu, HH Cao, Y Zhang, H Wang, ZJ Petrek, F Shi, EA Josephs, T Ye
ACS sensors 6 (2), 371-379, 2020
62020
A ‘Semi-Protected Oligonucleotide Recombination’ Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches
EA Josephs, PE Marszalek
Nucleic acids research 45 (8), e63-e63, 2017
52017
Endonuclease-independent DNA mismatch repair processes on the lagging strand
EA Josephs, PE Marszalek
DNA repair 68, 41-49, 2018
32018
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Articles 1–20