Follow
Tobias Krojer
Tobias Krojer
MAX IV Laboratory
Verified email at maxiv.lu.se - Homepage
Title
Cited by
Cited by
Year
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
T Krojer, M Garrido-Franco, R Huber, M Ehrmann, T Clausen
Nature 416 (6879), 455-459, 2002
4902002
Structural basis for the regulated protease and chaperone function of DegP
T Krojer, J Sawa, E Schäfer, HR Saibil, M Ehrmann, T Clausen
Nature 453 (7197), 885-890, 2008
4282008
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ...
Journal of Biological Chemistry 288 (11), 7803-7814, 2013
2992013
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ...
Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011
2792011
Rapid covalent-probe discovery by electrophile-fragment screening
E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ...
Journal of the American Chemical Society 141 (22), 8951-8968, 2019
2482019
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8, 15123, 2017
2422017
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ...
Cell Stem Cell 29 (2), 217-231. e8, 2022
1812022
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
1772013
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain
OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ...
Chemical science 7 (3), 2322-2330, 2016
1692016
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
1602012
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins
T Krojer, K Pangerl, J Kurt, J Sawa, C Stingl, K Mechtler, R Huber, ...
Proceedings of the National Academy of Sciences 105 (22), 7702-7707, 2008
1572008
Substrate-induced remodeling of the active site regulates human HTRA1 activity
L Truebestein, A Tennstaedt, T Mönig, T Krojer, F Canellas, M Kaiser, ...
Nature Structural and Molecular Biology 18 (3), 386, 2011
1542011
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues
T Krojer, J Sawa, R Huber, T Clausen
Nature Structural and Molecular Biology 17 (7), 844, 2010
1362010
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
M Schuller, GJ Correy, S Gahbauer, D Fearon, T Wu, RE Díaz, ID Young, ...
Science advances 7 (16), eabf8711, 2021
1342021
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
R Chowdhury, R Sekirnik, NC Brissett, T Krojer, C Ho, SS Ng, IJ Clifton, ...
Nature 510 (7505), 422-426, 2014
1222014
Crystal structure of the 2-oxoglutarate-and Fe (II)-dependent lysyl hydroxylase JMJD6
M Mantri, T Krojer, EA Bagg, CJ Webby, DS Butler, G Kochan, ...
Journal of molecular biology 401 (2), 211-222, 2010
1072010
Gentle, fast and effective crystal soaking by acoustic dispensing
PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017
1032017
The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination
T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017
1012017
Structural and mechanistic studies on γ-butyrobetaine hydroxylase
IKH Leung, TJ Krojer, GT Kochan, L Henry, F von Delft, TDW Claridge, ...
Chemistry & biology 17 (12), 1316-1324, 2010
1012010
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
V Bavetsias, RM Lanigan, GF Ruda, B Atrash, MG McLaughlin, A Tumber, ...
Journal of medicinal chemistry 59 (4), 1388-1409, 2016
1002016
The system can't perform the operation now. Try again later.
Articles 1–20