Yuntao Xia
Yuntao Xia
Orchid Health
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DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration
J Irianto, Y Xia, CR Pfeifer, A Athirasala, J Ji, C Alvey, M Tewari, ...
Current biology 27 (2), 210-223, 2017
Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest
S Cho, M Vashisth, A Abbas, S Majkut, K Vogel, Y Xia, IL Ivanovska, ...
Developmental cell 49 (6), 920-935. e5, 2019
Mechanotransduction in cancer
LK Chin, Y Xia, DE Discher, PA Janmey
Current opinion in chemical engineering 11, 77-84, 2016
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors
Y Xia, IL Ivanovska, K Zhu, L Smith, J Irianto, CR Pfeifer, CM Alvey, J Ji, ...
Journal of Cell Biology 217 (11), 3796-3808, 2018
Nuclear constriction segregates mobile nuclear proteins away from chromatin
J Irianto, CR Pfeifer, RR Bennett, Y Xia, IL Ivanovska, AJ Liu, ...
Molecular biology of the cell 27 (25), 4011-4020, 2016
SIRPA-inhibited, marrow-derived macrophages engorge, accumulate, and differentiate in antibody-targeted regression of solid tumors
CM Alvey, KR Spinler, J Irianto, CR Pfeifer, B Hayes, Y Xia, S Cho, ...
Current Biology 27 (14), 2065-2077. e6, 2017
Constricted migration increases DNA damage and independently represses cell cycle
CR Pfeifer, Y Xia, K Zhu, D Liu, J Irianto, VMM García, LMS Millán, ...
Molecular biology of the cell 29 (16), 1948-1962, 2018
Accurate genomic variant detection in single cells with primary template-directed amplification
V Gonzalez-Pena, S Natarajan, Y Xia, D Klein, R Carter, Y Pang, ...
Proceedings of the National Academy of Sciences 118 (24), e2024176118, 2021
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle
Y Xia, CR Pfeifer, K Zhu, J Irianto, D Liu, K Pannell, EJ Chen, LJ Dooling, ...
Journal of Cell Biology 218 (8), 2545-2563, 2019
SnapShot: mechanosensing matrix
J Irianto, CR Pfeifer, Y Xia, DE Discher
Cell 165 (7), 1820-1820. e1, 2016
As a nucleus enters a small pore, chromatin stretches and maintains integrity, even with DNA breaks
J Irianto, Y Xia, CR Pfeifer, RA Greenberg, DE Discher
Biophysical journal 112 (3), 446-449, 2017
Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A, C in iPS-derived mesenchymal stem cells
S Cho, A Abbas, J Irianto, IL Ivanovska, Y Xia, M Tewari, DE Discher
Nucleus 9 (1), 235-250, 2018
Constricted migration modulates stem cell differentiation
LR Smith, J Irianto, Y Xia, CR Pfeifer, DE Discher
Molecular biology of the cell 30 (16), 1985-1999, 2019
Nuclear mechanics during and after constricted migration
Y Xia, CR Pfeifer, DE Discher
Acta Mechanica Sinica 35, 299-308, 2019
Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review
CR Pfeifer, M Vashisth, Y Xia, DE Discher
Essays in Biochemistry 63 (5), 569-577, 2019
Nuclear mechanosensing
Y Xia, CR Pfeifer, S Cho, DE Discher, J Irianto
Emerging topics in life sciences 2 (5), 713-725, 2018
Elastic-fluid model for DNA damage and mutation from nuclear fluid segregation due to cell migration
RR Bennett, CR Pfeifer, J Irianto, Y Xia, DE Discher, AJ Liu
Biophysical journal 112 (11), 2271-2279, 2017
Scaling concepts in ‘omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis
M Vashisth, S Cho, J Irianto, Y Xia, M Wang, B Hayes, D Wieland, R Wells, ...
Proceedings of the National Academy of Sciences 118 (48), e2112940118, 2021
Multivalent, soluble nano-self peptides increase phagocytosis of antibody-opsonized targets while suppressing “Self” signaling
AAR Jalil, BH Hayes, JC Andrechak, Y Xia, DM Chenoweth, DE Discher
ACS nano 14 (11), 15083-15093, 2020
Constricted cell migration causes nuclear lamina damage, DNA breaks, and squeeze-out of repair factors
J Irianto, CR Pfeifer, Y Xia, A Athirasala, IL Ivanovska, RA Greenberg, ...
bioRxiv, 035626, 2015
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