Benjamin Werner
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Identification of neutral tumor evolution across cancer types
MJ Williams, B Werner, CP Barnes, TA Graham, A Sottoriva
Nature genetics 48 (3), 238-244, 2016
Quantification of subclonal selection in cancer from bulk sequencing data
MJ Williams, B Werner, T Heide, C Curtis, CP Barnes, A Sottoriva, ...
Nature genetics 50 (6), 895-903, 2018
Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial
KH Khan, D Cunningham, B Werner, G Vlachogiannis, I Spiteri, T Heide, ...
Cancer discovery 8 (10), 1270-1285, 2018
Subclonal reconstruction of tumors by using machine learning and population genetics
G Caravagna, T Heide, MJ Williams, L Zapata, D Nichol, K Chkhaidze, ...
Nature genetics 52 (9), 898-907, 2020
Evolutionary dynamics of neoantigens in growing tumors
E Lakatos, MJ Williams, RO Schenck, WCH Cross, J Househam, L Zapata, ...
Nature genetics 52 (10), 1057-1066, 2020
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
A Acar, D Nichol, J Fernandez-Mateos, GD Cresswell, I Barozzi, SP Hong, ...
Nature communications 11 (1), 1923, 2020
Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions
B Werner, F Beier, S Hummel, S Balabanov, L Lassay, T Orlikowsky, ...
eLife, e08687v2, 2015
Phenotypic plasticity and genetic control in colorectal cancer evolution
J Househam, T Heide, GD Cresswell, I Spiteri, C Kimberley, L Zapata, ...
Nature 611 (7937), 744-753, 2022
Dynamics of mutant cells in hierarchical organized tissues
B Werner, D Dingli, T Lenaerts, JM Pacheco, A Traulsen
PLoS computational biology 7 (12), e1002290, 2011
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
K Chkhaidze, T Heide, B Werner, MJ Williams, W Huang, G Caravagna, ...
PLoS computational biology 15 (7), e1007243, 2019
The evolutionary dynamics of extrachromosomal DNA in human cancers
JT Lange, JC Rose, CY Chen, Y Pichugin, L Xie, J Tang, KL Hung, ...
Nature genetics 54 (10), 1527-1533, 2022
Evolutionary dynamics of residual disease in human glioblastoma
I Spiteri, G Caravagna, GD Cresswell, A Vatsiou, D Nichol, A Acar, ...
Annals of Oncology 30 (3), 456-463, 2019
The cancer stem cell fraction in hierarchically organized tumors can be estimated using mathematical modeling and patient-specific treatment trajectories
B Werner, JG Scott, A Sottoriva, ARA Anderson, A Traulsen, PM Altrock
Cancer research 76 (7), 1705-1713, 2016
Measuring single cell divisions in human tissues from multi-region sequencing data
B Werner, J Case, MJ Williams, K Chkhaidze, D Temko, ...
Nature communications 11 (1), 1035, 2020
A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues
B Werner, D Dingli, A Traulsen
Journal of The Royal Society Interface 10 (85), 20130349, 2013
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
MJ Williams, L Zapata, B Werner, CP Barnes, A Sottoriva, TA Graham
Elife 9, e48714, 2020
Dynamics of leukemia stem-like cell extinction in acute promyelocytic leukemia
B Werner, RE Gallagher, EM Paietta, MR Litzow, MS Tallman, PH Wiernik, ...
Cancer research 74 (19), 5386-5396, 2014
Should tissue structure suppress or amplify selection to minimize cancer risk?
L Hindersin, B Werner, D Dingli, A Traulsen
Biology direct 11, 1-11, 2016
Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity
W Huang, A Traulsen, B Werner, T Hiltunen, L Becks
Nature Communications 8 (1), 2059, 2017
Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates
B Werner, A Sottoriva
PLoS computational biology 14 (6), e1006233, 2018
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