Wei Shen Aik
Wei Shen Aik
Assistant Professor, Hong Kong Baptist University
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Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases
WS Aik, MA McDonough, A Thalhammer, R Chowdhury, CJ Schofield
Current opinion in structural biology 22 (6), 691-700, 2012
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
WS Aik, JS Scotti, H Choi, L Gong, M Demetriades, CJ Schofield, ...
Nucleic acids research 42 (7), 4741-4754, 2014
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation
C Xu, K Liu, W Tempel, M Demetriades, WS Aik, CJ Schofield, J Min
Journal of Biological Chemistry 289 (25), 17299-17311, 2014
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
WS Aik, M Demetriades, MKK Hamdan, EAL Bagg, KK Yeoh, C Lejeune, ...
Journal of medicinal chemistry 56 (9), 3680-3688, 2013
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition
J Brem, SS Van Berkel, WS Aik, AM Rydzik, MB Avison, I Pettinati, ...
Nature chemistry 6 (12), 1084-1090, 2014
Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir
HS Lo, KPY Hui, HM Lai, X He, KS Khan, S Kaur, J Huang, Z Li, ...
ACS central science 7 (5), 792-802, 2021
Structure of an active human histone pre-mRNA 3′-end processing machinery
Y Sun, Y Zhang, WS Aik, XC Yang, WF Marzluff, T Walz, Z Dominski, ...
Science 367 (6478), 700-703, 2020
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation
JS Scotti, IKH Leung, W Ge, MA Bentley, J Paps, HB Kramer, J Lee, ...
Proceedings of the National Academy of Sciences 111 (37), 13331-13336, 2014
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase
ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ...
Journal of medicinal chemistry 55 (5), 2173-2184, 2012
Pharmacological inhibition of FTO
F McMurray, M Demetriades, WS Aik, M Merkestein, H Kramer, ...
PLoS One 10 (4), e0121829, 2015
Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes. In 2-oxoglutarate-dependent oxygenases
WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ...
R. Soc. Chem. Cambridge, 59-94, 2015
Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes
S Kaur, NY Tam, MA McDonough, CJ Schofield, WS Aik
Nucleic Acids Research 50 (7), 4148-4160, 2022
Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio-and stereoselectivity of prolyl hydroxylases
S Horita, JS Scotti, C Thinnes, YS Mottaghi-Taromsari, A Thalhammer, ...
Structure 23 (4), 639-652, 2015
Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes
WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ...
Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction
Y Wu, WS Tam, HF Chau, S Kaur, W Thor, WS Aik, WL Chan, ...
Chemical Science 11 (41), 11266-11273, 2020
Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5′–3′ exonuclease
X Yang, Y Sun, WS Aik, WF Marzluff, L Tong, Z Dominski
Rna 26 (10), 1345-1359, 2020
The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
A Thalhammer, WS Aik, EAL Bagg, CJ Schofield
Drug Discovery Today: Therapeutic Strategies 9 (2-3), e91-e100, 2012
Composition and processing activity of a semi-recombinant holo U7 snRNP
K Bucholc, WS Aik, X Yang, K Wang, ZH Zhou, M Dadlez, WF Marzluff, ...
Nucleic acids research 48 (3), 1508-1530, 2020
The N-terminal domains of FLASH and Lsm11 form a 2: 1 heterotrimer for histone pre-mRNA 3’-end processing
WS Aik, MH Lin, D Tan, A Tripathy, WF Marzluff, Z Dominski, CY Chou, ...
PLoS One 12 (10), e0186034, 2017
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