A methodology for performing global uncertainty and sensitivity analysis in systems biology S Marino, IB Hogue, CJ Ray, DE Kirschner Journal of theoretical biology 254 (1), 178-196, 2008 | 2803 | 2008 |
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms JT Mattila, OO Ojo, D Kepka-Lenhart, S Marino, JH Kim, SY Eum, LE Via, ... The Journal of Immunology 191 (2), 773-784, 2013 | 386 | 2013 |
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization HP Gideon, JY Phuah, AJ Myers, BD Bryson, MA Rodgers, MT Coleman, ... PLoS pathogens 11 (1), e1004603, 2015 | 344 | 2015 |
Dynamic balance of pro‐and anti‐inflammatory signals controls disease and limits pathology JM Cicchese, S Evans, C Hult, LR Joslyn, T Wessler, JA Millar, S Marino, ... Immunological reviews 285 (1), 147-167, 2018 | 290 | 2018 |
Mathematical modeling of primary succession of murine intestinal microbiota S Marino, NT Baxter, GB Huffnagle, JF Petrosino, PD Schloss Proceedings of the National Academy of Sciences 111 (1), 439-444, 2014 | 230 | 2014 |
The human immune response to Mycobacterium tuberculosis in lung and lymph node S Marino, DE Kirschner Journal of theoretical biology 227 (4), 463-486, 2004 | 226 | 2004 |
Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection S Marino, NA Cilfone, JT Mattila, JJ Linderman, JAL Flynn, DE Kirschner Infection and immunity 83 (1), 324-338, 2015 | 217 | 2015 |
Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation M Fallahi-Sichani, M El-Kebir, S Marino, DE Kirschner, JJ Linderman The Journal of Immunology 186 (6), 3472-3483, 2011 | 200 | 2011 |
Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs SD Chakravarty, G Zhu, MC Tsai, VP Mohan, S Marino, DE Kirschner, ... Infection and immunity 76 (3), 916-926, 2008 | 200 | 2008 |
Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis S Marino, S Pawar, CL Fuller, TA Reinhart, JAL Flynn, DE Kirschner The Journal of Immunology 173 (1), 494-506, 2004 | 200 | 2004 |
Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo T Repasy, J Lee, S Marino, N Martinez, DE Kirschner, G Hendricks, ... PLoS pathogens 9 (2), e1003190, 2013 | 149 | 2013 |
TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model S Marino, A Myers, JAL Flynn, DE Kirschner Journal of theoretical biology 265 (4), 586-598, 2010 | 116 | 2010 |
Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue S Marino, D Sud, H Plessner, PL Lin, J Chan, JAL Flynn, DE Kirschner PLoS computational biology 3 (10), e194, 2007 | 115 | 2007 |
A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis S Marino, M El-Kebir, D Kirschner Journal of theoretical biology 280 (1), 50-62, 2011 | 105 | 2011 |
Regulation of glycolysis in Lactococcus lactis: an unfinished systems biological case study EO Voit, J Almeida, S Marino, R Lall, G Goel, AR Neves, H Santos IEE Proceedings-Systems Biology 153 (4), 286-298, 2006 | 99 | 2006 |
A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment D Kirschner, E Pienaar, S Marino, JJ Linderman Current opinion in systems biology 3, 170-185, 2017 | 81 | 2017 |
Data-parallel algorithms for agent-based model simulation of tuberculosis on graphics processing units. RM D'Souza, M Lysenko, S Marino, DE Kirschner SpringSim, 2009 | 81 | 2009 |
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity–mediated antimicrobial responses with caseation during Mycobacterium … NA Cilfone, CB Ford, S Marino, JT Mattila, HP Gideon, JAL Flynn, ... The Journal of Immunology 194 (2), 664-677, 2015 | 77 | 2015 |
Understanding the immune response in tuberculosis using different mathematical models and biological scales D Gammack, S Ganguli, S Marino, J Segovia-Juarez, DE Kirschner Multiscale Modeling & Simulation 3 (2), 312-345, 2005 | 73 | 2005 |
Characterizing the dynamics of CD4+ T cell priming within a lymph node JJ Linderman, T Riggs, M Pande, M Miller, S Marino, DE Kirschner The Journal of Immunology 184 (6), 2873-2885, 2010 | 71 | 2010 |