colin Fishwick
colin Fishwick
Professor of Medicinal Chemistry, University of Leeds
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pH as a trigger of peptide β-sheet self-assembly and reversible switching between nematic and isotropic phases
A Aggeli, M Bell, LM Carrick, CWG Fishwick, R Harding, PJ Mawer, ...
Journal of the American Chemical Society 125 (32), 9619-9628, 2003
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
S Uppal, CP Diggle, IM Carr, CWG Fishwick, M Ahmed, GH Ibrahim, ...
Nature genetics 40 (6), 789-793, 2008
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
J Brem, R Cain, S Cahill, MA McDonough, IJ Clifton, ...
Nature communications 7 (1), 12406, 2016
Structure-based discovery of antibacterial drugs
KJ Simmons, I Chopra, CWG Fishwick
Nature Reviews Microbiology 8 (7), 501-510, 2010
Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques
JG Hurdle, AJ O'neill, E Ingham, C Fishwick, I Chopra
Antimicrobial Agents and Chemotherapy 48 (11), 4366-4376, 2004
Structures of helical β-tapes and twisted ribbons: the role of side-chain interactions on twist and bend behavior
CWG Fishwick, AJ Beevers, LM Carrick, CD Whitehouse, A Aggeli, ...
Nano letters 3 (11), 1475-1479, 2003
Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to …
AJ O'Neill, T Huovinen, CWG Fishwick, I Chopra
Antimicrobial agents and chemotherapy 50 (1), 298-309, 2006
Adsorption and self‐assembly of peptides on mica substrates
C Whitehouse, J Fang, A Aggeli, M Bell, R Brydson, CWG Fishwick, ...
Angewandte Chemie International Edition 44 (13), 1965-1968, 2005
Cyclic boronates inhibit all classes of β-lactamases
ST Cahill, R Cain, DY Wang, CT Lohans, DW Wareham, HP Oswin, ...
Antimicrobial agents and chemotherapy 61 (4), 10.1128/aac. 02260-16, 2017
High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors
LF Wetherill, KK Holmes, M Verow, M Müller, G Howell, M Harris, ...
Journal of virology 86 (9), 5341-5351, 2012
Assay platform for clinically relevant metallo-β-lactamases
SS van Berkel, J Brem, AM Rydzik, R Salimraj, R Cain, A Verma, ...
Journal of medicinal chemistry 56 (17), 6945-6953, 2013
RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus
A O'Neill, B Oliva, C Storey, A Hoyle, C Fishwick, I Chopra
Antimicrobial agents and chemotherapy 44 (11), 3163-3166, 2000
Self-assembling β-sheet tape forming peptides
RPW Davies, A Aggeli, AJ Beevers, N Boden, LM Carrick, CWG Fishwick, ...
Supramolecular Chemistry 18 (5), 435-443, 2006
The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors
KL Blake, AJ O'Neill, D Mengin‐Lecreulx, PJF Henderson, JM Bostock, ...
Molecular microbiology 72 (2), 335-343, 2009
Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human and Plasmodium falciparum Dihydroorotate Dehydrogenases
M Davies, T Heikkila, GA McConkey, CWG Fishwick, MR Parsons, ...
Journal of medicinal chemistry 52 (9), 2683-2693, 2009
Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro
C StGelais, TL Foster, M Verow, E Atkins, CWG Fishwick, D Rowlands, ...
Journal of virology 83 (16), 7970-7981, 2009
Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel
TL Foster, M Verow, AL Wozniak, MJ Bentham, J Thompson, E Atkins, ...
Hepatology 54 (1), 79-90, 2011
Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase Center
K Miller, CJ Dunsmore, CWG Fishwick, I Chopra
Antimicrobial agents and chemotherapy 52 (5), 1737-1742, 2008
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
T Heikkilä, S Thirumalairajan, M Davies, MR Parsons, AG McConkey, ...
Bioorganic & medicinal chemistry letters 16 (1), 88-92, 2006
Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase
T Heikkilä, C Ramsey, M Davies, C Galtier, AMW Stead, AP Johnson, ...
Journal of medicinal chemistry 50 (2), 186-191, 2007
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