pH as a trigger of peptide β-sheet self-assembly and reversible switching between nematic and isotropic phases A Aggeli, M Bell, LM Carrick, CWG Fishwick, R Harding, PJ Mawer, ... Journal of the American Chemical Society 125 (32), 9619-9628, 2003 | 601 | 2003 |
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy S Uppal, CP Diggle, IM Carr, CWG Fishwick, M Ahmed, GH Ibrahim, ... Nature genetics 40 (6), 789-793, 2008 | 355 | 2008 |
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates J Brem, R Cain, S Cahill, MA McDonough, IJ Clifton, ... Nature communications 7 (1), 12406, 2016 | 258 | 2016 |
Structure-based discovery of antibacterial drugs KJ Simmons, I Chopra, CWG Fishwick Nature Reviews Microbiology 8 (7), 501-510, 2010 | 189 | 2010 |
Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques JG Hurdle, AJ O'neill, E Ingham, C Fishwick, I Chopra Antimicrobial agents and chemotherapy 48 (11), 4366-4376, 2004 | 177 | 2004 |
Structures of helical β-tapes and twisted ribbons: the role of side-chain interactions on twist and bend behavior CWG Fishwick, AJ Beevers, LM Carrick, CD Whitehouse, A Aggeli, ... Nano letters 3 (11), 1475-1479, 2003 | 166 | 2003 |
Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to … AJ O'Neill, T Huovinen, CWG Fishwick, I Chopra Antimicrobial agents and chemotherapy 50 (1), 298-309, 2006 | 149 | 2006 |
Adsorption and self‐assembly of peptides on mica substrates C Whitehouse, J Fang, A Aggeli, M Bell, R Brydson, CWG Fishwick, ... Angewandte Chemie International Edition 44 (13), 1965-1968, 2005 | 143 | 2005 |
Cyclic boronates inhibit all classes of β-lactamases ST Cahill, R Cain, DY Wang, CT Lohans, DW Wareham, HP Oswin, ... Antimicrobial agents and chemotherapy 61 (4), 10.1128/aac. 02260-16, 2017 | 139 | 2017 |
High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors LF Wetherill, KK Holmes, M Verow, M Müller, G Howell, M Harris, ... Journal of virology 86 (9), 5341-5351, 2012 | 135 | 2012 |
Assay platform for clinically relevant metallo-β-lactamases SS van Berkel, J Brem, AM Rydzik, R Salimraj, R Cain, A Verma, ... Journal of medicinal chemistry 56 (17), 6945-6953, 2013 | 130 | 2013 |
Self-assembling β-sheet tape forming peptides RPW Davies, A Aggeli, AJ Beevers, N Boden, LM Carrick, CWG Fishwick, ... Supramolecular Chemistry 18 (5), 435-443, 2006 | 118 | 2006 |
The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors KL Blake, AJ O'Neill, D Mengin‐Lecreulx, PJF Henderson, JM Bostock, ... Molecular microbiology 72 (2), 335-343, 2009 | 113 | 2009 |
RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus A O'Neill, B Oliva, C Storey, A Hoyle, C Fishwick, I Chopra Antimicrobial agents and chemotherapy 44 (11), 3163-3166, 2000 | 110 | 2000 |
Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human and Plasmodium falciparum Dihydroorotate Dehydrogenases M Davies, T Heikkila, GA McConkey, CWG Fishwick, MR Parsons, ... Journal of medicinal chemistry 52 (9), 2683-2693, 2009 | 106 | 2009 |
Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel TL Foster, M Verow, AL Wozniak, MJ Bentham, J Thompson, E Atkins, ... Hepatology 54 (1), 79-90, 2011 | 90 | 2011 |
Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro C StGelais, TL Foster, M Verow, E Atkins, CWG Fishwick, D Rowlands, ... Journal of virology 83 (16), 7970-7981, 2009 | 90 | 2009 |
Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase Center K Miller, CJ Dunsmore, CWG Fishwick, I Chopra Antimicrobial agents and chemotherapy 52 (5), 1737-1742, 2008 | 87 | 2008 |
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase T Heikkilä, S Thirumalairajan, M Davies, MR Parsons, AG McConkey, ... Bioorganic & medicinal chemistry letters 16 (1), 88-92, 2006 | 86 | 2006 |
Inhibition of D-Ala: D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine S Batson, C de Chiara, V Majce, AJ Lloyd, S Gobec, D Rea, V Fülöp, ... Nature communications 8 (1), 1939, 2017 | 83 | 2017 |