Xavier Morelli
Xavier Morelli
Cancer Research Center of Marseille (CRCM), CNRS
Verified email at - Homepage
Cited by
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Structural basis of membrane binding by Gla domains of vitamin K–dependent proteins
M Huang, AC Rigby, X Morelli, MA Grant, G Huang, B Furie, B Seaton, ...
Nature Structural & Molecular Biology 10 (9), 751-756, 2003
Chemical and structural lessons from recent successes in protein–protein interaction inhibition (2P2I)
X Morelli, R Bourgeas, P Roche
Current opinion in chemical biology 15 (4), 475-481, 2011
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes
M Bouvet, A Lugari, CC Posthuma, JC Zevenhoven, S Bernard, S Betzi, ...
Journal of Biological Chemistry 289 (37), 25783-25796, 2014
2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions
MJ Basse, S Betzi, R Bourgeas, S Bouzidi, B Chetrit, V Hamon, X Morelli, ...
Nucleic acids research 41 (D1), D824-D827, 2012
Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database
R Bourgeas, MJ Basse, X Morelli, P Roche
PloS one 5 (3), e9598, 2010
Protein–protein interaction inhibition (2P2I) combining high throughput and virtual screening: application to the HIV-1 Nef protein
S Betzi, A Restouin, S Opi, ST Arold, I Parrot, F Guerlesquin, X Morelli, ...
Proceedings of the National Academy of Sciences 104 (49), 19256-19261, 2007
Exploring selective inhibition of the first bromodomain of the human bromodomain and extra-terminal domain (BET) proteins
B Raux, Y Voitovich, C Derviaux, A Lugari, E Rebuffet, S Milhas, S Priet, ...
Journal of medicinal chemistry 59 (4), 1634-1641, 2016
Heteronuclear NMR and Soft Docking:  An Experimental Approach for a Structural Model of the Cytochrome c553−Ferredoxin Complex
X Morelli, A Dolla, M Czjzek, PN Palma, F Blasco, L Krippahl, JJG Moura, ...
Biochemistry 39 (10), 2530-2537, 2000
2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions
MJ Basse, S Betzi, X Morelli, P Roche
Database 2016, baw007, 2016
GFscore: a general nonlinear consensus scoring function for high-throughput docking
S Betzi, K Suhre, B Chétrit, F Guerlesquin, X Morelli
Journal of chemical information and modeling 46 (4), 1704-1712, 2006
Molecular mapping of the RNA Cap 2′-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16
A Lugari, S Betzi, E Decroly, E Bonnaud, A Hermant, JC Guillemot, ...
Journal of Biological Chemistry 285 (43), 33230-33241, 2010
A novel approach for assesing macromolecular complexes combining soft‐docking calculations with NMR data
XJ Morelli, PN Palma, F Guerlesquin, AC Rigby
Protein Science 10 (10), 2131-2137, 2001
Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity
C Salmi-Smail, A Fabre, F Dequiedt, A Restouin, R Castellano, S Garbit, ...
Journal of medicinal chemistry 53 (8), 3038-3047, 2010
Integrated strategy for lead optimization based on fragment growing: the diversity-oriented-target-focused-synthesis approach
L Hoffer, YV Voitovich, B Raux, K Carrasco, C Muller, AY Fedorov, ...
Journal of medicinal chemistry 61 (13), 5719-5732, 2018
Structural Model of the Fe-Hydrogenase/Cytochromec 553 Complex Combining Transverse Relaxation-optimized Spectroscopy Experiments and Soft Docking Calculations
X Morelli, M Czjzek, CE Hatchikian, O Bornet, JC Fontecilla-Camps, ...
Journal of Biological Chemistry 275 (30), 23204-23210, 2000
Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR
C Bernard, S Gely, JM Bourhis, X Morelli, S Longhi, H Darbon
FEBS letters 583 (7), 1084-1089, 2009
Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130
F Hu, X Shi, B Li, X Huang, X Morelli, N Shi
Journal of Biological Chemistry 290 (44), 26373-26382, 2015
Structural basis for the interaction between Golgi reassembly-stacking protein GRASP55 and Golgin45
J Zhao, B Li, X Huang, X Morelli, N Shi
Journal of Biological Chemistry 292 (7), 2956-2965, 2017
Chemistry‐driven hit‐to‐lead optimization guided by structure‐based approaches
L Hoffer, C Muller, P Roche, X Morelli
Molecular Informatics 37 (9-10), 1800059, 2018
2P2IHUNTER: a tool for filtering orthosteric protein–protein interaction modulators via a dedicated support vector machine
V Hamon, R Bourgeas, P Ducrot, I Theret, L Xuereb, MJ Basse, JM Brunel, ...
Journal of The Royal Society Interface 11 (90), 20130860, 2014
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