David Mowrey
David Mowrey
Senior Research Scientist, Icagen-T
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Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine
J Pan, Q Chen, D Willenbring, D Mowrey, XP Kong, A Cohen, CB Divito, ...
Structure 20 (9), 1463-1469, 2012
NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites
V Bondarenko, DD Mowrey, TS Tillman, E Seyoum, Y Xu, P Tang
Biochimica et Biophysica Acta (BBA)-Biomembranes 1838 (5), 1389-1395, 2014
p62-dependent phase separation of patient-derived KEAP1 mutations and NRF2
EW Cloer, PF Siesser, EM Cousins, D Goldfarb, DD Mowrey, JS Harrison, ...
Molecular and cellular biology, 2018
Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels
D Mowrey, MH Cheng, LT Liu, D Willenbring, X Lu, T Wymore, Y Xu, ...
Journal of the American Chemical Society 135 (6), 2172-2180, 2013
Insights into distinct modulation of α7 and α7β2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane
DD Mowrey, Q Liu, V Bondarenko, Q Chen, E Seyoum, Y Xu, J Wu, ...
Journal of Biological Chemistry 288 (50), 35793-35800, 2013
Conformational changes underlying desensitization of the pentameric ligand-gated ion channel ELIC
MN Kinde, Q Chen, MJ Lawless, DD Mowrey, J Xu, S Saxena, Y Xu, ...
Structure 23 (6), 995-1004, 2015
Open-channel structures of the human glycine receptor α1 full-length transmembrane domain
DD Mowrey, T Cui, Y Jia, D Ma, AM Makhov, P Zhang, P Tang, Y Xu
Structure 21 (10), 1897-1904, 2013
Isoflurane Alters the Structure and Dynamics of GLIC
D Willenbring, LT Liu, D Mowrey, Y Xu, P Tang
Biophysical Journal 101 (8), 1905-1912, 2011
Percolation model of sensory transmission and loss of consciousness under general anesthesia
DW Zhou, DD Mowrey, P Tang, Y Xu
Physical review letters 115 (10), 108103, 2015
NMR structures of the transmembrane domains of the α4β2 nAChR
V Bondarenko, D Mowrey, T Tillman, T Cui, LT Liu, Y Xu, P Tang
Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (5), 1261-1268, 2012
NMR Structure and Dynamics of Water-Solubilized Transmembrane Domains of Nicotinic Acetylcholine Receptor
T Cui, D Mowrey, V Bondarenko, T Tillman, D Ma, E Landrum, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes, 2011
NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChR
V Bondarenko, D Mowrey, LT Liu, Y Xu, P Tang
Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (2), 398-404, 2013
β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology
EA Proctor, DD Mowrey, NV Dokholyan
PLoS computational biology 15 (7), e1007225, 2019
Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain
MM Wells, TS Tillman, DD Mowrey, T Sun, Y Xu, P Tang
Journal of medicinal chemistry 58 (7), 2958-2966, 2015
Signal transduction pathways in the pentameric ligand-gated ion channels
D Mowrey, Q Chen, Y Liang, J Liang, Y Xu, P Tang
PLoS One 8 (5), e64326, 2013
ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation
TS Tillman, E Seyoum, DD Mowrey, Y Xu, P Tang
Journal of Biological Chemistry 289 (20), 13851-13857, 2014
Tyrosine phosphorylation switching of a G protein
B Li, M Tunc-Ozdemir, D Urano, H Jia, EG Werth, DD Mowrey, LM Hicks, ...
Journal of Biological Chemistry 293 (13), 4752-4766, 2018
Unresponsive Correlated Motion in α7 nAChR to Halothane Binding Explains Its Functional Insensitivity to Volatile Anesthetics
D Mowrey, EJ Haddadian, LT Liu, D Willenbring, Y Xu, P Tang
The Journal of Physical Chemistry B 114 (22), 7649-7655, 2010
Channel gating dependence on pore lining helix glycine residues in skeletal muscle ryanodine receptor
Y Mei, L Xu, DD Mowrey, RM Giraldez, Y Wang, DA Pasek, NV Dokholyan, ...
Journal of Biological Chemistry 290 (28), 17535-17545, 2015
Atomistic insights into human Cys-loop receptors by solution NMR
DD Mowrey, MN Kinde, Y Xu, P Tang
Biochimica et Biophysica Acta (BBA)-Biomembranes 1848 (1), 307-314, 2015
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