| Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions DG Lupiáñez, K Kraft, V Heinrich, P Krawitz, F Brancati, E Klopocki, ... Cell 161 (5), 1012-1025, 2015 | 2075 | 2015 |
| Formation of new chromatin domains determines pathogenicity of genomic duplications M Franke, DM Ibrahim, G Andrey, W Schwarzer, V Heinrich, R Schöpflin, ... Nature 538 (7624), 265-269, 2016 | 675 | 2016 |
| Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish A Hruscha, P Krawitz, A Rechenberg, V Heinrich, J Hecht, C Haass, ... Development 140 (24), 4982-4987, 2013 | 580 | 2013 |
| Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog) AJ Will, G Cova, M Osterwalder, WL Chan, L Wittler, N Brieske, V Heinrich, ... Nature genetics 49 (10), 1539-1545, 2017 | 190* | 2017 |
| Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis BK Kragesteen, M Spielmann, C Paliou, V Heinrich, R Schöpflin, ... Nature genetics 50 (10), 1463-1473, 2018 | 170 | 2018 |
| Preformed chromatin topology assists transcriptional robustness of Shh during limb development C Paliou, P Guckelberger, R Schöpflin, V Heinrich, A Esposito, ... Proceedings of the National Academy of Sciences 116 (25), 12390-12399, 2019 | 139 | 2019 |
| Characterization of hundreds of regulatory landscapes in developing limbs reveals two regimes of chromatin folding G Andrey, R Schöpflin, I Jerković, V Heinrich, DM Ibrahim, C Paliou, ... Genome research 27 (2), 223-233, 2017 | 137 | 2017 |
| Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma K Helmsauer, ME Valieva, S Ali, R Chamorro González, R Schöpflin, ... Nature communications 11 (1), 5823, 2020 | 127 | 2020 |
| Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations K Kraft, A Magg, V Heinrich, C Riemenschneider, R Schöpflin, ... Nature cell biology 21 (3), 305-310, 2019 | 117 | 2019 |
| Hi-C identifies complex genomic rearrangements and TAD-shuffling in developmental diseases US Melo, R Schöpflin, R Acuna-Hidalgo, MA Mensah, B Fischer-Zirnsak, ... The American Journal of Human Genetics 106 (6), 872-884, 2020 | 106 | 2020 |
| Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator L Allou, S Balzano, A Magg, M Quinodoz, B Royer-Bertrand, R Schöpflin, ... Nature 592 (7852), 93-98, 2021 | 89 | 2021 |
| The allele distribution in next-generation sequencing data sets is accurately described as the result of a stochastic branching process V Heinrich, J Stange, T Dickhaus, P Imkeller, U Krüger, S Bauer, ... Nucleic acids research 40 (6), 2426-2431, 2012 | 55 | 2012 |
| Homozygous and compound-heterozygous mutations in TGDS cause Catel-Manzke syndrome N Ehmke, A Caliebe, R Koenig, SG Kant, Z Stark, V Cormier-Daire, ... The American Journal of Human Genetics 95 (6), 763-770, 2014 | 51 | 2014 |
| Filtering for compound heterozygous sequence variants in non-consanguineous pedigrees T Kamphans, P Sabri, N Zhu, V Heinrich, S Mundlos, PN Robinson, ... PLoS One 8 (8), e70151, 2013 | 51 | 2013 |
| The mole genome reveals regulatory rearrangements associated with adaptive intersexuality F M. Real, SA Haas, P Franchini, P Xiong, O Simakov, H Kuhl, R Schöpflin, ... Science 370 (6513), 208-214, 2020 | 46 | 2020 |
| Screening for single nucleotide variants, small indels and exon deletions with a next‐generation sequencing based gene panel approach for U sher syndrome PM Krawitz, D Schiska, U Krüger, S Appelt, V Heinrich, D Parkhomchuk, ... Molecular genetics & genomic medicine 2 (5), 393-401, 2014 | 36 | 2014 |
| Estimating exome genotyping accuracy by comparing to data from large scale sequencing projects V Heinrich, T Kamphans, J Stange, D Parkhomchuk, J Hecht, T Dickhaus, ... Genome Medicine 5, 1-11, 2013 | 32 | 2013 |
| Somatic neurofibromatosis type 1 (NF1) inactivation events in cutaneous neurofibromas of a single NF1 patient D Emmerich, T Zemojtel, J Hecht, P Krawitz, M Spielmann, J Kühnisch, ... European Journal of Human Genetics 23 (6), 870-873, 2015 | 26 | 2015 |
| Strategisches Umweltcontrolling mit Hilfe der Balanced Scorecard M Fahrbach, V Heinrich, R Pfitzner UmweltWirtschaftsForum 8 (2), 41-44, 2000 | 26 | 2000 |
| CRUP: a comprehensive framework to predict condition-specific regulatory units A Ramisch, V Heinrich, LV Glaser, A Fuchs, X Yang, P Benner, ... Genome biology 20, 1-23, 2019 | 25 | 2019 |
